Results 201 to 210 of about 29,159 (222)
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Genistein as an anti-inflammatory agent
Inflammation Research, 2003The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice.Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with
Rikard Holmdahl +3 more
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EFFECTS OF ORAL GENISTEIN IN MICE
Pediatric Pathology & Molecular Medicine, 2003In cell culture systems, genistein, a soy-derived isoflavone with chemopreventive and estrogenic effects, enhances cAMP-dependent activation of the most common cystic fibrosis-causing mutation, deltaF508-CFTR, by as much as 20-fold. DeltaF508-CFTR is present in the apical membrane at far lower levels than wild-type CFTR. If genistein can enhance cyclic
William W. Reenstra +3 more
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PLASMA PHARMACOKINETICS OF GENISTEIN IN MICE
International Journal of Oncology, 1995Genistein (GEN) has recently generated considerable interest as a potential agent for the prevention and treatment of cancer. The present investigation was undertaken to determine if the concentrations of drug shown to inhibit the growth of human tumor cell lines by 50% in vitro (IC50=2-27 mu g/ml) can be achieved and sustained systemically in mice. We
Jg Supko, Louis Malspeis
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The genistein stimulon of Bradyrhizobium japonicum
Molecular Genetics and Genomics, 2008An initializing step in the rhizobia-legume symbiosis is the secretion of flavonoids by plants that leads to the expression of nodulation genes in rhizobia. Here we report the genome-wide transcriptional response of Bradyrhizobium japonicum to genistein, an isoflavone secreted by soybean. About 100 genes were induced in the wild type. This included all
Felix Hauser +3 more
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Radical scavenging properties of genistein
Free Radical Biology and Medicine, 2003The reactivity of genistein toward reactive radical species has been investigated by means of pulse radiolysis. The values of rate constants, respectively 2.3 x 10(10) M(-1)s(-1) and 1.3 x 10(10) M(-1)s(-1) for the reaction with hydroxyl radical at pH 8.3 and 3.0, are close to diffusion limit indicating that genistein is a potent hydroxyl radical ...
Grzegorz Grynkiewicz +2 more
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THE EFFECT OF GENISTEIN ON THE FERTILITY OF MICE
Journal of Endocrinology, 1955SUMMARY Synthetic genistein, 5:7:4′-trihydroxy-isoflavone, proved to be oestrogenic (that is to say produced vaginal cornification) when included in the normal diet of immature, spayed and intact female mice in amounts calculated to give daily intakes of 2, 10 and 15 mg respectively. Consumption of genistein also precipitated vaginal opening in
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2017
Genistein (4,5,7-trihydroxyisoflavone) is a typical example of a phytoestrogenic compound, polyphenolic isoflavone, found in soy products, obtained primarily from Genista tinctoria L. in 1899 and named after the genus of this plant. Genistein is synthesized through transfer of (2S)-naringin into genistein by NAD(P)H in aerobic conditions and in the ...
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Genistein (4,5,7-trihydroxyisoflavone) is a typical example of a phytoestrogenic compound, polyphenolic isoflavone, found in soy products, obtained primarily from Genista tinctoria L. in 1899 and named after the genus of this plant. Genistein is synthesized through transfer of (2S)-naringin into genistein by NAD(P)H in aerobic conditions and in the ...
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Transcriptional Inhibition of CYP24 by Genistein
Annals of the New York Academy of Sciences, 2002Abstract: 1,25 Dihydroxyvitamin D3 (1,25‐D3) can be considered an antitumorigenic agent, which can be used in the therapy of malignant diseases such as prostate cancer. In this respect, it is important to note that some prostatic cancer cells express high levels of CYP24, a cytochrome enzyme involved in degradation of 1,25‐D3.
Heide S. Cross, Hesso Farhan
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Evidence for genistein as a mitochondriotropic molecule
Mitochondrion, 2016Genistein (4',5,7-trihydroxyisoflavone; C15H10O5), an isoflavone, has been investigated as an anti-cancer agent due to its ability to trigger cell death (both intrinsic and extrinsic apoptotic pathways) in different cancer cells in vitro and in vivo. Furthermore, genistein has been viewed as a mitochondriotropic molecule due to the direct effects this ...
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Genistein attenuates choroidal neovascularization
The Journal of Nutritional Biochemistry, 2014Genistein is a dietary-derived flavonoid abundantly present in soybeans and known to possess various biological effects including anti-inflammation and anti-angiogenic activity. To investigate the effects of genistein on intraocular neovascularization, we used an animal model of laser-induced choroidal neovascularization (CNV).
Junichi Fukuhara +9 more
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