Results 41 to 50 of about 31,152 (194)

The phytoestrogen genistein affects zebrafish development through two different pathways. [PDF]

PLoS ONE, 2009
BACKGROUND: Endocrine disrupting chemicals are widely distributed in the environment and derive from many different human activities or can also be natural products synthesized by plants or microorganisms.
Sana Sassi-Messai, Yann Gibert, Laure Bernard, Shin-Ichi Nishio, Karine F Ferri Lagneau, José Molina, Monika Andersson-Lendahl, Gérard Benoit, Patrick Balaguer, Vincent Laudet   +9 more
doaj   +1 more source

Genistein Targets STING-Driven Antiviral Responses

mBio, 2022
Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in infected and adjacent cells through intercellular ...
Tomalika R. Ullah, Katherine R. Balka, Rebecca L. Ambrose, Geneviève Pépin, Matthew C. J. Wilce, Jacqueline A. Wilce, Belinda J. Thomas, Dominic De Nardo, Bryan R. G. Williams, Michael P. Gantier   +9 more
doaj   +1 more source

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

Food Frontiers, EarlyView.
The molecular mechanism for mulberrin regulating lipid metabolism homeostasis. ABSTRACT Lipid metabolism disorders and the induced metabolic diseases have risen to become one of the primary public health issues. Our preliminary experimental results confirmed that mulberry leaf flavonoid extract exhibited efficacy in lipid metabolism regulation; the ...
Qian Li, Daorui Pang, Erna Li, Dongxu Xing, Fan Liu, Li Wang, Yuxiao Zou   +6 more
wiley   +1 more source

Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-κB/slug/E-cadherin pathway

BMC Cancer, 2017
Background Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown.
Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi, Aike Li   +5 more
doaj   +1 more source

Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects

Future Postharvest and Food, EarlyView.
ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq, Sajad Ahmad Mir, Zahida Naseem   +2 more
wiley   +1 more source

Genistein Prevents Nitric Oxide Deficiency-Induced Cardiac Dysfunction and Remodeling in Rats

Antioxidants, 2021
Genistein is an isoflavone found in soybeans. This study evaluates the protective effects of genistein on Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension, cardiac remodeling, and dysfunction in rats.
Anuson Poasakate, Putcharawipa Maneesai, Siwayu Rattanakanokchai, Sarawoot Bunbupha, Terdthai Tong-Un, Poungrat Pakdeechote   +5 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Comparison of simulated gastrointestinal digestion platforms with varying complexity and sample mass requirements, using common bean (Phaseolus vulgaris L.) as a model

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Measuring bioaccessible nutrient levels during digestion in a physiologically relevant (dynamic) manner is a bottleneck in plant breeding and food product development. The first aim of this study was to develop and compare four simulated gastric digestion models paired with a static small‐intestinal phase for use with small sample ...
Tayah M Bolt, Margaret Riggs, Weiyi Sun, Shu Yu, Larry Lerno, Li Tian, Paul Gepts, Antonia Palkovic, Travis A Parker, Gail M Bornhorst, Christine H Diepenbrock   +10 more
wiley   +1 more source

Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Plant‐lignans are polyphenols with low bioavailability and bioactivity that are transformed by the intestinal microbiota into enterolignans. Our hypotheses are: (i) the way in which plant‐lignans are ingested in the diet affects, in a decisive way, the microbial metabolism of these compounds and (ii) an increase in lignan ...
Susana Langa, José Antonio Curiel, Ruiz de la Bastida, Ángela Peirotén, José María Landete   +4 more
wiley   +1 more source