Reevaluation of the Roles of ABCG2 in the Disposition of Genistein [PDF]
Drug Metabolism and Disposition, 2012 The purpose of this letter is to clarify some assessments in the article by [Yang et al. (2012)][1], in which they questioned the credibility of a conclusion in our recently published article ([Alvarez et al., 2011][2]). [Yang et al.
Ana I. Alvarez +6 more
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Developmental toxicity and brain aromatase induction by high genistein concentrations in zebrafish embryos [PDF]
, 2009 Genistein is a phytoestrogen found at a high level in soybeans. In vitro and in vivo studies showed that high concentrations of genistein caused toxic effects.
Akiyama T +32 more
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The Bone-Protective Effect of Genistein in the Animal Model of Bilateral Ovariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-Menopausal Osteoporosis [PDF]
, 2011 Genistein, a major phytoestrogen of soy, is considered a potential drug for the prevention and treatment of post-menopausal osteoporosis. Mounting evidence suggested a positive correlation between genistein consumption and bone health both in vivo and in
Adlercreutz +39 more
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The role of Phytoestrogens in the management of menopausal symptoms [PDF]
, 2012 Menopause reflects a change in the woman’s physiological hormonal status and is regarded as a pivotal point in a woman’s life. The commonest symptoms experienced by women during the menopause are hot flushes and night sweats.
Avendonk, Tania van
core
Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. [PDF]
, 2016 Prostate carcinogenesis involves alterations in several signaling pathways, the most prominent being the PI3K/AKT pathway. This pathway is constitutively active and drives prostate cancer (PCa) progression to advanced metastatic disease. PTEN, a critical
Chowdhary, Harshika +19 more
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Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]
, 2010 Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Albini, Adriana +9 more
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Isoflavone content and antioxidant properties of soybean seeds [PDF]
, 2011 The isoflavone content and antioxidant properties of five Croatian soybean seed cultivars from two locations were analysed. The content of total and individual isofavones was determined by high performance liquid chromatography.
Edina Šertović +6 more
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Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study [PDF]
, 2016 Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to ...
Atkin, Stephen L. +5 more
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Biotransformed product, genistein 7-O-phosphate, enhances the oral bioavailability of genistein
Journal of Functional Foods, 2015 Research has indicated the health beneficial effects of soyfoods. Genistein, one of the primary bioactive agents in soybeans, has a number of pharmacological and biological activities; however, its low water solubility and low intestinal permeability may lead to the depletion of genistein absorption from dietary intake and contribute to its poor oral ...
Chia-Hao Chen +5 more
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The radioprotectant nano-genistein enhances radiotherapy efficacy of lung tumors in mice [PDF]
, 2023 BACKGROUND: Radiotherapy for non-small cell lung cancer (NSCLC) can be dose-limiting due to treatment-related toxicities. Genistein has been shown to be a robust radioprotective agent in preclinical models.
Brown, Stephen L +7 more
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