Results 241 to 250 of about 2,067,653 (305)

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

O26: Analysis of patient-reported outcomes and a functional assessment from 3-year nitisinone treatment trial in patients with alkaptonuria

Genetics in Medicine Open
Kathryn Spears, Francis Rossignol, Monique Perry, Joy Bryant, William Gahl, Wendy Introne   +5 more
doaj   +1 more source

Recent advances in methods to characterize archaic introgression in modern humans. [PDF]

Genome Res
Peede D, Bañuelos MM, Medina Tretmanis J, Miyagi M, Huerta-Sánchez E.   +4 more
europepmc   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

enhancer3D: 3D chromatin structures and enhancer-promoter distance profiles for archaic and modern human genomes. [PDF]

Nucleic Acids Res
Wlasnowolski M, Kozlov N, Wojcik M, Jacobs GS, Plewczynski D.   +4 more
europepmc   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Discovering the complete enhancer map of human herpesviruses using a natural language processing model. [PDF]

Nat Commun
Roy Chowdhury N, Ghosal D, Gurevich V, Shamay M.   +3 more
europepmc   +1 more source

Pangenome dynamics and population structure of the zoonotic pathogen Salmonella enterica serotype Hadar. [PDF]

Nat Commun
Tagg KA, Peñil-Celis A, Webb HE, Stapleton GS, Ellison Z, Leeper M, Kim JY, Simmons M, Tillman G, Li C, Harris B, Morningstar-Shaw BR, Steele MK, Mallal D, Matzinger S, Manion K, Hergert J, Wagner JM, Schwensohn C, Brandenburg JM, Shaw S, Benedict K, Folster JP, Dessai U, Redondo-Salvo S, Garcillan-Barcia MP, de la Cruz F.   +26 more
europepmc   +1 more source

PolyA_DB v4: systematic polyA site identification and isoform annotation in human and mouse genomes using 3' end and long-read sequencing data. [PDF]

Nucleic Acids Res
Yu S, Chen WC, Wang L, Jewell S, Mammedova A, Han SW, Wickramasinghe J, Barash Y, Tian B.   +8 more
europepmc   +1 more source