Results 21 to 30 of about 10,859,104 (346)

Transposable element insertions have strongly affected human evolution [PDF]

open access: yes, 2010
Comparison of a full collection of the transposable element (TE) sequences of vertebrates with genome sequences shows that the human genome makes 655 perfect full-length matches.
Britten, Roy J.
core   +2 more sources

Expansión clónica y caracterización genómica del proceso de integración del virus linfotrópico humano tipo I en la leucemia/linfoma de células T en adultos

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2009
Introducción. Aunque la integración del virus linfotrópico humano tipo I no es al azar, se desconocen muchos de los detalles de este proceso. Objetivo. Evaluar las características de la cromatina celular adyacente a secuencias provirales en pacientes con
Mercedes Salcedo-Cifuentes   +7 more
doaj   +1 more source

The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration

open access: yesnpj Regenerative Medicine, 2021
Throughout their lifetime, fish maintain a high capacity for regenerating complex tissues after injury. We utilized a larval tail regeneration assay in the zebrafish Danio rerio, which serves as an ideal model of appendage regeneration due to its easy ...
Jason W. Sinclair   +11 more
doaj   +1 more source

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

open access: yesGenome Biology, 2009
Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of ...
Ben Langmead   +3 more
semanticscholar   +1 more source

Genome maps across 26 human populations reveal population-specific patterns of structural variation. [PDF]

open access: yes, 2019
Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in ...
Cao, Han   +25 more
core   +2 more sources

Genomics and human diversity [PDF]

open access: yesCahiers de l’Urmis, 2021
The sequencing of the human genome (2003) has been followed by a number of technical developments that allow detailed characterization (including complete sequencing) of the DNA of thousands of individuals. This has provided an estimate of human genetic diversity: approx. 3 million base substitutions within our genome that includes 3,000 million bases.
openaire   +2 more sources

Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence [PDF]

open access: yes, 2003
BACKGROUND: Previous studies have suggested that recent segmental duplications, which are often involved in chromosome rearrangements underlying genomic disease, account for some 5% of the human genome.
Cheung, Joseph   +6 more
core   +2 more sources

Phenotypic variance explained by local ancestry in admixed African Americans

open access: yesFrontiers in Genetics, 2015
We surveyed 26 quantitative traits and disease outcomes to understand the proportion of phenotypic variance explained by local ancestry in admixed African Americans. After inferring local ancestry as the number of African-ancestry chromosomes at hundreds
Daniel eShriner   +6 more
doaj   +1 more source

From metagenomics to the metagenome: Conceptual change and the rhetoric of translational genomic research [PDF]

open access: yes, 2009
As the international genomic research community moves from the tool-making efforts of the Human Genome Project into biomedical applications of those tools, new metaphors are being suggested as useful to understanding how our genes work – and for ...
Huss, John Edward, Juengst, Eric Thomas
core   +1 more source

Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease

open access: yesNature Communications, 2021
PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are ...
Stephen Watt   +26 more
doaj   +1 more source

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