Results 61 to 70 of about 1,052,313 (231)

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

EOGD: the Euplotes octocarinatus genome database

BMC Genomics, 2018
Background Euplotes, a ciliated protozoan, is a useful unicellular model organism. Studies on Euplotes have provided excellent insights into various basic biological principles.
Ruan-lin Wang, Wei Miao, Wei Wang, Jie Xiong, Ai-hua Liang   +4 more
doaj   +1 more source

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing

BMC Genomics, 2012
BackgroundTheileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod ...
Sonal P. Henson, R. Bishop, S. Morzaria, P. Spooner, R. Pelle, L. Poveda, M. Ebeling, Erich Küng, U. Certa, C. Daubenberger, W. Qi   +10 more
semanticscholar   +1 more source

Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions [PDF]

, 2016
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis.
Ben Mamoun, Choukri, Brancato, Jana, Chibucos, Marcus, Colinge, Jacques, Cornillot, Emmanuel, Crabtree, Jonathan, Dwivedi, Ankit, Fraser, Claire M., Frutos, Roger, Gotia, Hanzel T., Hung, Chris, Ifeonu, Olukemi O., Krause, Peter J., Kumar, Vidya, Kumari, Priti, Lawres, Lauren, McCracken, Carrie, Molina, Douglas M., Orvis, Joshua, Ott, Sandy, Pablo, Jozelyn V., Pazzi, Joseph E., Reynes, Christelle, Sadzewicz, Lisa, Sengamalay, Naomi, Shetty, Amol C., Silva, Joana C., Su, Qi, Tallon, Luke, Tretina, Kyle, Usmani-Brown, Sahar, Virji, Azan Z.   +31 more
core   +3 more sources

A Genome-Wide Over-Expression Screen Identifies Genes Involved in Phagocytosis in the Human Protozoan Parasite, Entamoeba histolytica

PLoS ONE, 2012
Functional genomics and forward genetics seek to assign function to all known genes in a genome. Entamoeba histolytica is a protozoan parasite for which forward genetics approaches have not been extensively applied.
A. King, B. H. Welter, A. Koushik, Lindsay N. Gordon, L. Temesvari   +4 more
semanticscholar   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania [PDF]

, 2016
The Rad9-Rad1-Hus1 (9-1-1) complex is a key component in the coordination of DNA damage sensing, cell cycle progression and DNA repair pathways in eukaryotic cells. This PCNA-related trimer is loaded onto RPA-coated single stranded DNA and interacts with
Damasceno, Jeziel D., McCulloch, Richard, Obonaga, Ricardo, Santos, Elaine V., Scott, Alan, Tosi, Luiz R.O.   +5 more
core   +1 more source

Mapping the Trypanosoma cruzi Genome: Analyses of Representative Cosmid Libraries

BioTechniques, 1996
In order to generate contiguous cosmid coverage of the genome of the protozoan parasite Trypanosoma cruzi for large-scale sequence analysis, a cosmid library of 36864 individual, primary clones was generated.
J. Hanke, D.O. Sánchez, J. Henriksson, L. Åslund, U. Pettersson, A.C.C. Frasch, J.D. Hoheisel   +6 more
doaj   +1 more source

Effective Genome Editing in Leishmania (Viannia) braziliensis Stably Expressing Cas9 and T7 RNA Polymerase

Frontiers in Cellular and Infection Microbiology, 2021
Until 2015, loss-of-function studies to elucidate protein function in Leishmania relied on gene disruption through homologous recombination. Then, the CRISPR/Cas9 revolution reached these protozoan parasites allowing efficient genome editing with one ...
Caroline R. Espada, José C. Quilles, A. Albuquerque-Wendt, M. Cruz, T. Beneke, L. Lorenzon, E. Gluenz, A. Cruz, Silvia R. B. Uliana   +8 more
semanticscholar   +1 more source

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun, Di Ma, Wuqiong Zhang, Shuai Hou, Zhiqing Chen, Xuewei Li, Hongmei Meng, Daguang Zhang   +7 more
wiley   +1 more source