Results 91 to 100 of about 2,398,369 (345)
Multipartite viruses: A decentralized mode of functioning. [O.24] [PDF]
, 2015 Multipartite viruses are characterized by a genome composed of two or more nucleic acid segments, each encapsidated indivually. A classical view in virology assumes that the viral replication cycle occurs within individual cells, where the whole viral ...
Blanc, Stéphane +4 more
core
Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data [PDF]
, 2015 There is a high prevalence of coronary artery disease (CAD) in patients with left bundle branch block (LBBB); however there are many other causes for this electrocardiographic abnormality.
Haydon, Daniel T. +6 more
core +2 more sources
Genes & Development, 2015 In this study, Chiou et al. describe a novel system for titratable tumor initiation in the adult pancreas through retrograde ductal injection of adenoviral-Cre-expressing and lentiviral-Cre-expressing vectors.
S. Chiou +16 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: Isolation and characterization of viable and nonviable mutants [PDF]
, 1988 By following a strategy of genetic analysis of poliovirus, we have constructed a synthetic "mutagenesis cartridge" spanning the genome-linked viral protein coding region and flanking cleavage sites in an infectious cDNA clone of the type 1 (Mahoney ...
Dunn, John J. +5 more
core
Evolution of foot-and-mouth disease virus intra-sample sequence diversity during serial transmission in bovine hosts [PDF]
, 2013 RNA virus populations within samples are highly heterogeneous, containing a large number of minority sequence variants which can potentially be transmitted to other susceptible hosts. Consequently, consensus genome sequences provide an incomplete picture
Haydon, D.T. +6 more
core +2 more sources
The landscape of viral associations in human cancers
Nature Genetics, 2020 Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
M. Zapatka +26 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Viruses, 2019 Although Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber’s Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear.
Eva Ramírez de Arellano +16 more
doaj +1 more source
RNA Structures and Their Role in Selective Genome Packaging
Viruses, 2021 To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye +7 more
doaj +1 more source