Results 71 to 80 of about 776,538 (310)

RNA Structures and Their Role in Selective Genome Packaging

Viruses, 2021
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth   +7 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Multipartite viruses: A decentralized mode of functioning. [O.24] [PDF]

, 2015
Multipartite viruses are characterized by a genome composed of two or more nucleic acid segments, each encapsidated indivually. A classical view in virology assumes that the viral replication cycle occurs within individual cells, where the whole viral ...
Blanc, Stéphane, Gutiérrez, Serafin, Michalakis, Yannis, Sicard, Anne, Vernerey, Marie-Stéphanie   +4 more
core  

Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants (Loxodonta africana)

Microbiology Spectrum, 2021
Distinct but related species of elephant endotheliotropic herpesviruses (EEHVs) circulate within Asian and African elephant populations. Primary infection with EEHVs endemic among Asian elephants can cause clinical illness and lethal EEHV hemorrhagic ...
Taylor Pursell, Jennifer L. Spencer Clinton, Jie Tan, Rongsheng Peng, Xiang Qin, Harshavardhan Doddapaneni, Vipin Menon, Zeineen Momin, Kavya Kottapalli, Lauren Howard, Erin Latimer, Sarah Heaggans, Gary S. Hayward, Paul D. Ling   +13 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Endogenous caulimovirid sequences are widespread in plant genomes [PDF]

, 2010
Endogenous sequences from members of the Caulimoviridae and Geminiviridae families have been identified in the genome of several plant species. They are thought to result from illegitimate recombination events and are generally replication-defective ...
Choisne, Nathalie, Geering, Andrew D., Quesneville, Hadi, Sharahskin, Tanya, Teycheney, Pierre-Yves, Velasco, Riccardo, Vezzulli, Silvia   +6 more
core  

CTL escape and viral fitness in HIV/SIV infection

Frontiers in Microbiology, 2012
Cytotoxic T lymphocyte (CTL) responses exert a suppressive effect on HIV and simian immunodeficiency virus (SIV) replication. Under the CTL pressure, viral CTL escape mutations are frequently selected for with viral fitness costs.
Sayuri eSeki, Sayuri eSeki, Tetsuro eMatano, Tetsuro eMatano   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and cerine residues in the Epstein-Barr Virus lytic switch protein [PDF]

, 2008
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with various malignancies, including Burkitt's lymphoma and nasopharyngeal carcinoma.
A Prokhortchouk, AJ Sinclair, Alison J. Sinclair, Bill Sugden, C Petosa, C Schelcher, C Schelcher, Carlo Petosa, Celine Schelcher, E Flemington, EA Merritt, Elizabeth Verrall, F Watt, G Miller, KF Macsween, LS Young, M Gromiha, MR Hicks, MR Hicks, N Nagano, P Wang, PM Bhende, PM Bhende, Questa H. Karlsson, R Feederle, RJ Klose, RM Esnouf, SJ Bark-Jones, T Tsurumi, TA Jones, U Heinemann, YF Chiu   +31 more
core   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source