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Genome-Wide Variation in Potyviruses [PDF]
Frontiers in Plant Science, 2019 Potyviruses (family Potyviridae, genus Potyvirus) are the result of an initial radiation event that occurred 6,600 years ago. The genus currently consists of 167 species that infect monocots or dicots, including domesticated and wild plants.
Deepti Nigam +3 more
doaj +3 more sources
Genome-wide profiling of uncapped mRNA [PDF]
, 2012 Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs ...
BD Gregory +9 more
core +6 more sources
Replication in Genome-Wide Association Studies
Statistical Science, 2010 Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases.
Ioannidis, John P. A. +2 more
core +6 more sources
Journal of Investigative Dermatology, 2013 WhaT is epiGeneTics? The term “epigenetics” was coined by Conrad Waddington to describe “the branch of biology which studies the causal interactions between genes and their products, which bring the phenotype into being” (Goldberg et al., 2007). Very broadly, the word has come to refer to the study of the regulation of genes, their expression, and how ...
Capell, Brian C., Berger, Shelley L.
openaire +2 more sources
Genome-wide inference of ancestral recombination graphs [PDF]
, 2013 The complex correlation structure of a collection of orthologous DNA sequences is uniquely captured by the "ancestral recombination graph" (ARG), a complete record of coalescence and recombination events in the history of the sample.
Gronau, Ilan +3 more
core +10 more sources
Genome Wide Methylome Alterations in Lung Cancer. [PDF]
PLoS ONE, 2015 Aberrant cytosine 5-methylation underlies many deregulated elements of cancer. Among paired non-small cell lung cancers (NSCLC), we sought to profile DNA 5-methyl-cytosine features which may underlie genome-wide deregulation.
Nandita Mullapudi +12 more
doaj +1 more source
Genome-wide somatic hypermutation [PDF]
Proceedings of the National Academy of Sciences, 2004 DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially dangerous, it has been hypothesized that mutations do not occur throughout the genome but instead are actively targeted to the Ig loci.
Clifford L, Wang +2 more
openaire +2 more sources
Myopia genetics in genome-wide association and post-genome-wide association study era [PDF]
International Journal of Ophthalmology, 2019 Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has ...
Xuan Liao, Qing-Qing Tan, Chang-Jun Lan
doaj +1 more source
Genome wide study of tardive dyskinesia in schizophrenia
Translational Psychiatry, 2021 Tardive dyskinesia (TD) is a severe condition characterized by repetitive involuntary movement of orofacial regions and extremities. Patients treated with antipsychotics typically present with TD symptomatology.
Keane Lim +13 more
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