Results 11 to 20 of about 1,251,540 (276)

Genome-wide search for strabismus susceptibility loci. [PDF]

, 2003
The purpose of this study was to search for chromosomal susceptibility loci for comitant strabismus. Genomic DNA was isolated from 10mL blood taken from each member of 30 nuclear families in which 2 or more siblings are affected by either esotropia or ...
Fujiwara, Hirotake, Hasebe, Satoshi, Kitada, Mizue, Matsuo, Toshihiko, Ohtsuki, Hiroshi, Sato, Masako, Yamane, Takashi   +6 more
core   +1 more source

Genome-wide studies of telomere biology in budding yeast

Microbial Cell, 2014
Telomeres are specialized DNA-protein structures at the ends of eukaryotic chromosomes. Telomeres are essential for chromosomal stability and integrity, as they prevent chromosome ends from being recognized as double strand breaks.
Yaniv Harari, Martin Kupiec
doaj   +1 more source

Genome-Wide Multiple Sclerosis Association Data and Coagulation [PDF]

, 2019
The emerging concept of a crosstalk between hemostasis, inflammation, and immune system prompt recent works on coagulation cascade in multiple sclerosis (MS).
Arianna Fornasiero, Giovanni Ristori, Marco Salvetti, Marco Salvetti, Maria Chiara Buscarinu, Michela Ferraldeschi, Renato Umeton, Renato Umeton, Rosella Mechelli, Sara La Starza, Silvia Romano   +10 more
core   +2 more sources

Genome-Wide Significance Levels and Weighted Hypothesis Testing [PDF]

, 2009
Genetic investigations often involve the testing of vast numbers of related hypotheses simultaneously. To control the overall error rate, a substantial penalty is required, making it difficult to detect signals of moderate strength.
Roeder, Kathryn, Wasserman, Larry
core   +1 more source

Creating a RAW264.7 CRISPR-Cas9 Genome Wide Library

Bio-Protocol, 2017
The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing tools are used in mammalian cells to knock-out specific genes of interest to elucidate gene function.
Brooke Napier , Denise Monack
doaj   +1 more source

Genome‐wide insights into introgression and its consequences for genome‐wide heterozygosity in the Mytilus species complex across Europe

Evolutionary Applications, 2020
The three mussel species comprising the Mytilus complex are widespread across Europe and readily hybridize when they occur in sympatry, resulting in a mosaic of populations with varying genomic backgrounds. Two of these species, M.
David L. J. Vendrami, Michele De Noia, Luca Telesca, Eva‐Maria Brodte, Joseph I. Hoffman   +4 more
doaj   +1 more source

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing [PDF]

, 2016
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels.
Adams, DJ, Aspden, RM, Bezzina, CR, Bhomra, A, Blizard, DA, Bopp, N, Brown, SD, Cai, N, Callebert, J, Cosgrove, C, Davies, RW, Flint, J, Franken, P, Fray, M, Goodstadt, L, Gregory, JS, Harrison, M, Hassett, C, Hernandez-Pliego, P, Hough, T, Joynson, R, Klenerman, P, Launay, JM, Lionikaite, V, Lionikas, A, Lodder, EM, McIntyre, RE, Mott, R, Nell, B, Nicod, J, Phelps, H, Pinto, YM, Potter, PK, Remme, CA, Robbins, PA, Rowe, C, Talbot, NP, Walling, A, Weaver, T, Wells, S, Wood, J, Yee, BK   +41 more
core   +1 more source

Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries

Scientific Reports, 2017
CRISPR-Cas9 technology has accelerated biological research becoming routine for many laboratories. It is rapidly replacing conventional gene editing techniques and has high utility for both genome-wide and gene-focussed applications.
Emmanouil Metzakopian, Alex Strong, Vivek Iyer, Alex Hodgkins, Konstantinos Tzelepis, Liliana Antunes, Mathias J Friedrich, Qiaohua Kang, Teresa Davidson, Jacob Lamberth, Christina Hoffmann, Gregory D. Davis, George S. Vassiliou, William C. Skarnes, Allan Bradley   +14 more
doaj   +1 more source

Genome wide analysis of Arabidopsis core promoters

BMC Genomics, 2005
Background Core promoters are the gene regulatory regions most proximal to the transcription start site (TSS), central to the formation of pre-initiation complexes and for combinatorial gene regulation.
Molina Carlos, Grotewold Erich
doaj   +1 more source

Genome-wide signatures of convergent evolution in echolocating mammals [PDF]

, 2013
Evolution is typically thought to proceed through divergence of genes, proteins, and ultimately phenotypes(1-3). However, similar traits might also evolve convergently in unrelated taxa due to similar selection pressures(4,5).
A Schneider, A Stamatakis, A Stamatakis, A Terrinoni, AF Ryan, AG Clark, AJ Drummond, AM Hancock, BP Lewis, EB Kim, EC Teeling, EC Teeling, Elia Stupka, G Jones, G Jones, G Li, G Parra, G Parra, G Zhang, Georgia Tsagkogeorga, HB Zhao, HB Zhao, J Castresana, James A. Cotton, JF Hughes, JI Fasick, Joe Parker, JP Bielawski, JZ Zhang, K Katoh, K Kriener, K Lindblad-Toh, KG Becker, KTJ Davies, M Kanehisa, M Soskine, M Vater, N Lartillot, OR Bininda-Emonds, Paolo Provero, PR Grant, R Li, R She, RC Edgar, RR Hoy, Stephen J. Rossiter, T Junier, TA Castoe, TSK Prasad, V Ranwez, W Huang da, WJ Murphy, WM Fitch, WS Wong, WWL Au, X Zhou, Y Benjamini, Y Liu, Y Liu, Y Liu, Y-B Sun, Y-Y Shen, Yuan Liu, Z Yang, Z Yang   +64 more
core   +1 more source