Results 191 to 200 of about 669,401 (295)

Genome-wide association study and fine-mapping identify a major quantitative trait locus controlling hundred-seed weight in soybean [PDF]

Chunlei Zhang, Huilong Hong, Rongqiang Yuan, Shiyao Zhang, Tianjiao Gao, Shuping Yan, Sobhi F. Lamlom, Honglei Ren, Zhangxiong Liu, Jiajun Wang   +9 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Immune cell signatures and preeclampsia: Unveiling causal links through genome-wide association studies. [PDF]

Medicine (Baltimore)
Zhang H, Zu Y, Xiu X, Yi H, Xu X, Yan J.
europepmc   +1 more source

Genome-wide association study to dissect the genetic architecture of bolting-related traits in carrot (Daucus carota) [PDF]

Xiaoping Kong, Jie Wu, Xiangping Yan, Feiyun Zhuang, Hongwei Zhou, Shaonan Xu, C. Ou   +6 more
openalex   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

FINEMAP-miss: fine-mapping genome-wide association studies with missing genotype information. [PDF]

Bioinformatics
Kartau J, Pirinen M.
europepmc   +1 more source

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

, 2018
Stuart MacGregor, Jue‐Sheng Ong, Jiyuan An, Xikun Han, Tiger Zhou, Owen M. Siggs, Matthew H. Law, Emmanuelle Souzeau, Shiwani Sharma, David J. Lynn, Jonathan Beesley, Bronwyn Sheldrick, Richard Mills, John Landers, Jonathan B. Ruddle, Stuart L. Graham, Paul R. Healey, Andrew White, Robert J. Casson, Stephen Best, John Grigg, Ivan Goldberg, Joseph E. Powell, David C. Whiteman, Graham Radford‐Smith, Nicholas G. Martin, Grant W. Montgomery, Kathryn P. Burdon, David A. Mackey, Puya Gharahkhani, Jamie E. Craig, Alex W. Hewitt   +31 more
openalex   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Sparse multitask group Lasso for genome-wide association studies. [PDF]

PLoS Comput Biol
Nouira A, Azencott CA.
europepmc   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source