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An Introduction to Genome-Wide Association Studies: GWAS for Dummies
Seminars in Reproductive Medicine, 2016Although the genetic origin of many human diseases and phenotypes has been long and widely recognized, identification of the causative gene alleles has been limited, slow, and cumbersome. This has changed substantially with the introduction of genome-wide association studies (GWASs) a decade ago, fueled by studies and reference projects of human ...
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Genome-wide association studies
Nature Reviews Methods Primers, 2021Emil Uffelmann +2 more
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A Genome-Wide Association Study (GWAS) of Takotsubo syndrome
European Heart JournalAbstract Background Takotsubo syndrome (TS) is an acute cardiac condition of unknown etiology characterized by transient regional systolic dysfunction of the left and/or right ventricle. Several studies have suggested the importance of genetics; however, studies are limited and have presented ...
H F K Hakansson, P Tornvall
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Overview of Statistical Methods for Genome-Wide Association Studies (GWAS)
2013This chapter provides an overview of statistical methods for genome-wide association studies (GWAS) in animals, plants, and humans. The simplest form of GWAS, a marker-by-marker analysis, is illustrated with a simple example. The problem of selecting a significance threshold that accounts for the large amount of multiple testing that occurs in GWAS is ...
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Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review
Progress in Neuro-Psychopharmacology and Biological PsychiatryImpulsivity is related to a host of mental and behavioral problems. It is a complex construct with many different manifestations, most of which are heritable. The genetic compositions of these impulsivity manifestations, however, remain unclear. A number of genome-wide association studies (GWAS) and post-GWAS analyses have tried to address this issue ...
Jiaqi, Wang +4 more
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[New insight of genome-wide association study (GWAS)].
Nihon rinsho. Japanese journal of clinical medicine, 2013The number of obese patients is increasing in Japan, due to the westernization of lifestyle. Obesity, especially visceral fat obesity, is important for the development of metabolic syndrome. Genetic factors are important for the development of obesity as well as environmental factors.
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Advancing the use of genome-wide association studies for drug repurposing
Nature Reviews Genetics, 2021Murray Cairns
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Pro: Genome-Wide Association Studies (GWAS) in Asthma
American Journal of Respiratory and Critical Care Medicine, 2011Scott T, Weiss, Edwin K, Silverman
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[From genome-wide association studies (gwas) to genome-wide polygenic scores (GPS)].
Medecine sciences : M/S, 2019The accumulation of extensive repositories linking phenotypic and genetic information, together with new computation methods, makes it possible to derive polygenic scores for susceptibility to common diseases that turn out to have strong predictive power.
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Genome-Wide Association Studies (GWAS) in Cereals
2021Braulio J. Soto-Cerda +3 more
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