Results 11 to 20 of about 42,338,399 (265)

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

open access: yesGenome Biology, 2022
Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering
Stavroula Kanoni   +538 more
doaj   +1 more source

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

open access: yesBreast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen   +56 more
doaj   +1 more source

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

open access: yesFrontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma   +10 more
doaj   +1 more source

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

open access: yesArthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu   +11 more
doaj   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

open access: yes, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo   +999 more
core   +1 more source

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]

open access: yes, 2011
Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...
Donovan, Jenny   +57 more
core   +1 more source

Genetic Predisposition to Neuroblastoma

open access: yesChildren, 2018
Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis.
Erin K. Barr, Mark A. Applebaum
doaj   +1 more source

I-GWAS: Privacy-Preserving Interdependent Genome-Wide Association Studies

open access: yes, 2022
Genome-wide Association Studies (GWASes) identify genomic variations that are statistically associated with a trait, such as a disease, in a group of individuals.
Decouchant, Jérémie (author)   +3 more
core   +1 more source

First genome-wide association study on anxiety-related behaviours in childhood [PDF]

open access: yes, 2013
Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B.   +66 more
core   +1 more source

Genome-wide association study of quality traits and starch pasting properties of maize kernels

open access: yesBMC Genomics, 2023
Background Starch are the main nutritional components of maize (Zea mays L.), and starch pasting properties are widely used as essential indicators for quality estimation.
Xinmei Guo   +5 more
doaj   +1 more source

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