Results 11 to 20 of about 191,340 (203)

Microbial genome-wide association studies: lessons from human GWAS [PDF]

Nature Reviews Genetics, 2016
AbstractThe reduced costs of sequencing have led to the availability of whole genome sequences for a large number of microorganisms, enabling the application of microbial genome wide association studies (GWAS). Given the successes of human GWAS in understanding disease aetiology and identifying potential drug targets, microbial GWAS is likely to ...
Power, Robert A., Parkhill, Julian, de Oliveira, Tulio   +2 more
openaire   +4 more sources

Genome-Wide Association Study (GWAS) of dental caries in diverse populations [PDF]

BMC Oral Health, 2021
Background Dental caries is one of the most common chronic diseases and is influenced by a complex interplay of genetic and environmental factors. Most previous genetic studies of caries have focused on identifying genes that contribute to dental caries ...
Rasha N. Alotaibi, Brian J. Howe, Jonathan M. Chernus, Nandita Mukhopadhyay, Carla Sanchez, Frederic W. B. Deleyiannis, Katherine Neiswanger, Carmencita Padilla, Fernando A. Poletta, Ieda M. Orioli, Carmen J. Buxó, Jacqueline T. Hecht, George L. Wehby, Ross E. Long, Alexandre R. Vieira, Seth M. Weinberg, John R. Shaffer, Lina M. Moreno Uribe, Mary L. Marazita   +18 more
doaj   +2 more sources

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Genome-Wide Association Study (GWAS) of Mesocotyl Length for Direct Seeding in Rice

Agronomy, 2021
Direct seeding is considered an efficient cultivation technology that reduces water use and labor costs. Mesocotyl length is one of the significant traits in cultivation; long mesocotyl is beneficial for the rate and uniformity of seedling emergence.
Seong-Gyu Jang, So-Yeon Park, San Mar Lar, Hongjia Zhang, Ah-Rim Lee, Fang-Yuan Cao, Jeonghwan Seo, Tae-Ho Ham, Joohyun Lee, Soon-Wook Kwon   +9 more
doaj   +1 more source

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium. [PDF]

, 2019
ObjectivePopulations of Mexican American ancestry are at an increased risk for nonalcoholic fatty liver disease. The objective of this study was to determine whether loci in known and novel genes were associated with variation in aspartate ...
Chen, Yii-Der I, Fingerlin, Tasha E, Goodarzi, Mark O, Guo, Xiuqing, Langefeld, Carl D, Norris, Jill M, Palmer, Nicholette D, Raffel, Leslie J, Rotter, Jerome I, Taylor, Kent D, Wagenknecht, Lynne E, Wang, Nan, Watanabe, Richard M, Williams, Adrienne H, Xiang, Anny H, Young, Kendra A   +15 more
core   +2 more sources

Genome-wide association study of quality traits and starch pasting properties of maize kernels

BMC Genomics, 2023
Background Starch are the main nutritional components of maize (Zea mays L.), and starch pasting properties are widely used as essential indicators for quality estimation.
Xinmei Guo, Zhaopeng Ge, Ming Wang, Meiai Zhao, Yuhe Pei, Xiyun Song   +5 more
doaj   +1 more source

Genetic susceptibility to feline infectious peritonitis in Birman cats. [PDF]

, 2013
Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal.
Golovko, Lyudmila, Liu, Hongwei, Lyons, Leslie A, Pedersen, Niels C, Sørensen, Anne, Wehnert, Suzanne   +5 more
core   +1 more source

nf-gwas-pipeline: A Nextflow Genome-Wide Association Study Pipeline [PDF]

Journal of Open Source Software, 2021
A tool for conducting Genome-Wide Association Study (GWAS) in a systematic, automated and reproducible manner is overdue. We developed an automated GWAS pipeline by combining multiple analysis tools - including bcftools, vcftools, the R packages SNPRelate/GENESIS/GMMAT and ANNOVAR - through Nextflow, which is a portable, flexible, and reproducible ...
Song, Zeyuan, Gurinovich, Anastasia, Federico, Anthony, Monti, Stefano, Sebastiani, Paola   +4 more
openaire   +2 more sources

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans [PDF]

, 2016
INTRODUCTION: African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.
, Barnes, Lisa L., Bennett, David A., Bourlas, Alexandra P., Buxbaum, Joseph D., Byrd, Goldie S., Chung, Jaeyoon, Crane, Paul K., Ertekin-Taner, Nilüfer, Evans, Denis, Fallin, M. Daniele, Farrer, Lindsay A., Foroud, Tatiana, Goate, Alison, Graff-Radford, Neill R., Haines, Jonathan L., Hall, Kathleen S., Jun, Gyungah, Kamboh, M. Ilyas, Kriegel, Joshua, Kukull, Walter A., Larson, Eric B., Logue, Mark W., Lunetta, Kathryn L., Manly, Jennifer J., Mayeux, Richard, Mez, Jesse, Pericak-Vance, Margaret A., Schellenberg, Gerard D., Sherva, Richard   +29 more
core   +1 more source