Results 11 to 20 of about 1,550,449 (243)

Characterising genome architectures using genome decomposition analysis [PDF]

BMC Genomics, 2021
AbstractGenome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression.
Eerik Aunin, Matthew Berriman, Adam James Reid   +2 more
openaire   +4 more sources

RAB18 is a key regulator of GalNAc-conjugated siRNA-induced silencing in Hep3B cells

Molecular Therapy: Nucleic Acids, 2022
Small interfering RNA (siRNA) therapeutics have developed rapidly in recent years, despite the challenges associated with delivery of large, highly charged nucleic acids.
Jiamiao Lu, Elissa Swearingen, Miki Hardy, Patrick Collins, Bin Wu, Eric Yuan, Daniel Lu, Chi-Ming Li, Songli Wang, Michael Ollmann   +9 more
doaj   +1 more source

StatsDB: platform-agnostic storage and understanding of next generation sequencing run metrics [v2; ref status: indexed, http://f1000r.es/2x1]

F1000Research, 2014
Modern sequencing platforms generate enormous quantities of data in ever-decreasing amounts of time. Additionally, techniques such as multiplex sequencing allow one run to contain hundreds of different samples.
Ricardo H. Ramirez-Gonzalez, Richard M. Leggett, Darren Waite, Anil Thanki, Nizar Drou, Mario Caccamo, Robert Davey   +6 more
doaj   +1 more source

StatsDB: platform-agnostic storage and understanding of next generation sequencing run metrics [v1; ref status: indexed, http://f1000r.es/28e]

F1000Research, 2013
Modern sequencing platforms generate enormous quantities of data in ever-decreasing amounts of time. Additionally, techniques such as multiplex sequencing allow one run to contain hundreds of different samples.
Ricardo H. Ramirez-Gonzalez, Richard M. Leggett, Darren Waite, Anil Thanki, Nizar Drou, Mario Caccamo, Robert Davey   +6 more
doaj   +1 more source

Epigenome-wide skeletal muscle DNA methylation profiles at the background of distinct metabolic types and ryanodine receptor variation in pigs

BMC Genomics, 2019
Background Epigenetic variation may result from selection for complex traits related to metabolic processes or appear in the course of adaptation to mediate responses to exogenous stressors.
Siriluck Ponsuksili, Nares Trakooljul, Sajjanar Basavaraj, Frieder Hadlich, Eduard Murani, Klaus Wimmers   +5 more
doaj   +1 more source

Global microRNA level regulation of EGFR‐driven cell‐cycle protein network in breast cancer

Molecular Systems Biology, 2012
The EGFR‐driven cell‐cycle pathway has been extensively studied due to its pivotal role in breast cancer proliferation and pathogenesis. Although several studies reported regulation of individual pathway components by microRNAs (miRNAs), little is known ...
Stefan Uhlmann, Heiko Mannsperger, Jitao David Zhang, Emöke‐Ágnes Horvat, Christian Schmidt, Moritz Küblbeck, Frauke Henjes, Aoife Ward, Ulrich Tschulena, Katharina Zweig, Ulrike Korf, Stefan Wiemann, Özgür Sahin   +12 more
doaj   +1 more source

A method to simultaneously construct up to 12 differently sized Illumina Nextera long mate pair libraries with reduced DNA input, time, and cost

BioTechniques, 2015
Long mate pair (LMP) or “jump” libraries are invaluable for producing contiguous genome assemblies and assessing structural variation. However the consistent production of high quality (low duplication rate, accurately sized) LMP libraries has proven ...
Darren Heavens, Gonzalo Garcia Accinelli, Bernardo Clavijo, Matthew Derek Clark   +3 more
doaj   +1 more source

Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets

BMC Genomics, 2017
Background High-grade serous ovarian carcinoma (HG-SOC) is the dominant tumor histologic type in epithelial ovarian cancers, exhibiting highly aberrant microRNA expression profiles and diverse pathways that collectively determine the disease ...
Vladimir A. Kuznetsov, Zhiqun Tang, Anna V. Ivshina   +2 more
doaj   +1 more source

The complete chloroplast genome of Sinomenium acutum (Menispermaceae)

Mitochondrial DNA. Part B. Resources, 2020
We generated the complete chloroplast genome sequence of Sinomenium acutum, a species of the Menispermaceae family, and characterized from the de novo assembly of Illumina HiSeq paired-end sequencing data. The total length of the chloroplast genome of S.
Jinhyuk Kim, Junki Lee, Sanghee Um, Sunseong Choi, Hyojin Kim, Hyang Sook Chun, Gyoungju Nah   +6 more
doaj   +1 more source

The complete chloroplast genome of Typhonium giganteum (Araceae)

Mitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome sequence of Typhonium giganteum, a species of the Araceae family, was characterized from the de novo assembly of HiSeq (Illumina Co.) paired-end sequencing data. The chloroplast genome of T.
Jinhyuk Kim, Junki Lee, Sunseong Choi, Sanghee Um, Hyojin Kim, Hyang Sook Chun, Gyoungju Nah   +6 more
doaj   +1 more source