Results 21 to 30 of about 1,550,449 (243)

Coordinated transcriptional and post-transcriptional epigenetic regulation during skeletal muscle development and growth in pigs

Journal of Animal Science and Biotechnology, 2022
Background N6-methyladenosine (m6A) and DNA 5-methylcytosine (5mC) methylation plays crucial roles in diverse biological processes, including skeletal muscle development and growth.
Du Zhang, Shumei Wu, Xinxin Zhang, Shuqiang Ren, Zhonglin Tang, Fei Gao   +5 more
doaj   +1 more source

Antibody Microarrays: Promises and Problems

BioTechniques, 2002
Antibody microarrays have enormous potential for becoming a tool that will allow, at the protein level, the type of global characterization of molecular mixtures that DNA microarrays already make possible at the RNA and DNA level.
Wlad Kusnezow, Jörg D. Hoheisel
doaj   +1 more source

Complete chloroplast genome of Gypsophila oldhamiana Miq. (Caryophyllales: Caryophyllaceae)

Mitochondrial DNA. Part B. Resources, 2021
The complete chloroplast genome sequence of Gypsophila oldhamiana Miq., a species of the Caryophyllaceae family, was assembled and analyzed from the de novo assembly of Illumina paired-end sequencing data. The total length of the chloroplast genome of G.
Ji Ran Jeong, Hyun Jo Koo, Heesu Yun, Hyang Sook Chun, Sang-Il Han, Gyoungju Nah   +5 more
doaj   +1 more source

Whole-exome sequencing uncovered the 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as the cause of lethal in a Vietnamese infant [PDF]

Exploration of Endocrine and Metabolic Diseases
Metabolic disorders are due to a deficiency of enzymes, which can severely impact health or cause serious complications without treatment. This study aimed to identify the molecular causes of an infant death who had been hospitalized with complicated ...
Hong Thu Nguyen-Huu, Khanh Linh Nguyen, Phuong Nhung Vu, Hai Ha Nguyen   +3 more
doaj   +1 more source

5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1

Journal of Experimental & Clinical Cancer Research, 2022
Background MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby ...
Xiaoya Li, Birgitta Elisabeth Michels, Oyku Ece Tosun, Janine Jung, Jolane Kappes, Susanne Ibing, Nishanth Belugali Nataraj, Shashwat Sahay, Martin Schneider, Angelika Wörner, Corinna Becki, Naveed Ishaque, Lars Feuerbach, Bernd Heßling, Dominic Helm, Rainer Will, Yosef Yarden, Karin Müller-Decker, Stefan Wiemann, Cindy Körner   +19 more
doaj   +1 more source

Spectrogram Analysis of Genomes [PDF]

EURASIP Journal on Advances in Signal Processing, 2004
We performed frequency-domain analysis in the genomes of various organisms using tricolor spectrograms, identifying several types of distinct visual patterns characterizing specific DNA regions. We relate patterns and their frequency characteristics to the sequence characteristics of the DNA.
Sussillo, David, Kundaje, Anshul, Anastassiou, Dimitris   +2 more
openaire   +3 more sources

Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment

Microbiome, 2017
Background Colonization by the pathogen Clostridium difficile often occurs in the background of a disrupted microbial community. Identifying specific organisms conferring resistance to invasion by C.
Sepideh Pakpour, Amit Bhanvadia, Roger Zhu, Abhimanyu Amarnani, Sean M. Gibbons, Thomas Gurry, Eric J. Alm, Laura A. Martello   +7 more
doaj   +1 more source

Whole genome transcriptome analysis [PDF]

RNA Biology, 2009
Recent studies indicate that the majority of the genome is transcribed, however only a fraction of this transcription is annotated as what we traditionally know as genes. Much of this is low level pervasive, and often overlapping transcription, for which the transcript structure and function, has not as yet been determined.
Forrest, Alistair, Carninci, Piero
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Systematic identification of intron retention associated variants from massive publicly available transcriptome sequencing data

Nature Communications, 2022
This paper proposed a novel in-silico framework for automatically screening disease-related variants and applied it to over 200,000 transcriptomes, providing an example to acquire medically relevant knowledge from publicly available sequence data.
Yuichi Shiraishi, Ai Okada, Kenichi Chiba, Asuka Kawachi, Ikuko Omori, Raúl Nicolás Mateos, Naoko Iida, Hirofumi Yamauchi, Kenjiro Kosaki, Akihide Yoshimi   +9 more
doaj   +1 more source