Genome annotation for clinical genomic diagnostics: strengths and weaknesses [PDF]
Genome Medicine, 2017 The Human Genome Project and advances in DNA sequencing technologies have revolutionized the identification of genetic disorders through the use of clinical exome sequencing.
Charles A. Steward +5 more
doaj +3 more sources
Welcome to the big leaves: Best practices for improving genome annotation in non‐model plant genomes [PDF]
Applications in Plant Sciences, 2023 Premise Robust standards to evaluate quality and completeness are lacking in eukaryotic structural genome annotation, as genome annotation software is developed using model organisms and typically lacks benchmarking to comprehensively evaluate the ...
Vidya S. Vuruputoor +10 more
doaj +2 more sources
Capturing heart valve development with Gene Ontology
Frontiers in Genetics, 2023 Introduction: The normal development of all heart valves requires highly coordinated signaling pathways and downstream mediators. While genomic variants can be responsible for congenital valve disease, environmental factors can also play a role. Later in
Saadullah H. Ahmed +4 more
doaj +1 more source
Workflows for Rapid Functional Annotation of Diverse Arthropod Genomes
Insects, 2021 Genome sequencing of a diverse array of arthropod genomes is already underway, and these genomes will be used to study human health, agriculture, biodiversity, and ecology.
Surya Saha +4 more
doaj +1 more source
Functional genome Annotation in Bacterial infections: A Review [PDF]
Al Ameen Journal of Medical Sciences, 2021 Functional annotation provides the information of gene about its biological identity and various types of molecular function and biological role like sub-cellular location and its expression.
Sharique Ahmad +3 more
doaj
Evaluation of three automated genome annotations for Halorhabdus utahensis. [PDF]
PLoS ONE, 2009 Genome annotations are accumulating rapidly and depend heavily on automated annotation systems. Many genome centers offer annotation systems but no one has compared their output in a systematic way to determine accuracy and inherent errors. Errors in the
Peter Bakke +12 more
doaj +1 more source
Best Practices for Comprehensive Annotation of Neuropeptides of Gryllus bimaculatus
Insects, 2023 Genome annotation is critically important data that can support research. Draft genome annotations cover representative genes; however, they often do not include genes that are expressed only in limited tissues and stages, or genes with low expression ...
Takako Mochizuki +8 more
doaj +1 more source
Progress, challenge and prospect of plant plastome annotation
Frontiers in Plant Science, 2023 The plastome (plastid genome) represents an indispensable molecular data source for studying phylogeny and evolution in plants. Although the plastome size is much smaller than that of nuclear genome, and multiple plastome annotation tools have been ...
Xiao-Jian Qu +6 more
doaj +1 more source
Efficient homology‐based annotation of transposable elements using minimizers
Applications in Plant Sciences, 2023 Premise Transposable elements (TEs) make up more than half of the genomes of complex plant species and can modulate the expression of neighboring genes, producing significant variability of agronomically relevant traits.
Laura Natalia Gonzalez‐García +4 more
doaj +1 more source
Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning [PDF]
, 2007 For modern biology, precise genome annotations are of prime importance, as they allow the accurate definition of genic regions. We employ state-of-the-art machine learning methods to assay and improve the accuracy of the genome annotation of the nematode
Bernhard Schölkopf +8 more
core +5 more sources