The rapid development of high-throughput sequencing technologies has led to a dramatic decrease in the money and time required for de novo genome sequencing or genome resequencing projects, with new genome sequences constantly released every week.
Wanfei Liu +8 more
doaj +1 more source
Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans [PDF]
The genomes of numerous parasitic nematodes are currently being sequenced, but their complexity and size, together with high levels of intra-specific sequence variation and a lack of reference genomes, makes their assembly and annotation a challenging ...
Gilleard John S. +34 more
core +1 more source
Status of genome function annotation in model organisms and crops
Since the entry into genome‐enabled biology several decades ago, much progress has been made in determining, describing, and disseminating the functions of genes and their products.
Bo Xue, Seung Y. Rhee
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High-throughput proteogenomics of
Background The structural and functional annotation of genomes is now heavily based on data obtained using automated pipeline systems. The key for an accurate structural annotation consists of blending similarities between closely related genomes with ...
Christie-Oleza Joseph A +10 more
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Genome annotation for clinical genomic diagnostics: strengths and weaknesses
The Human Genome Project and advances in DNA sequencing technologies have revolutionized the identification of genetic disorders through the use of clinical exome sequencing.
Charles A. Steward +5 more
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Improvements to the Gulf pipefish Syngnathus scovelli genome
The Gulf pipefish Syngnathus scovelli has emerged as an important species for studying sexual selection, development, and physiology. Comparative evolutionary genomics research involving fishes from Syngnathidae depends on having a high ...
Balan Ramesh +9 more
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AGMIAL: implementing an annotation strategy for prokaryote genomes as a distributed system [PDF]
We have implemented a genome annotation system for prokaryotes called AGMIAL. Our approach embodies a number of key principles. First, expert manual annotators are seen as a critical component of the overall system; user interfaces were cyclically ...
Loux, Valentin +33 more
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Galaxy Genome Annotation: Galaxy as a platform for the annotation of genomes
Galaxy Genome Annotation (GGA) is a project focusing on developments and resources to turn Galaxy into a complete and efficient platform for the structural and functional annotation of genome sequences. In this talk, we will present an update on the material produced by the GGA community in the last years on this topic.
Bretaudeau, Anthony, Rasche, Helena
openaire +1 more source
The Capsaspora genome reveals a complex unicellular prehistory of animals [PDF]
To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported
Chen, Zehua +19 more
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Towards Viral Genome Annotation Standards, Report from the 2010 NCBI Annotation Workshop
Improvements in DNA sequencing technologies portend a new era in virology and could possibly lead to a giant leap in our understanding of viral evolution and ecology.
Qiandong Zeng +14 more
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