Results 21 to 30 of about 429,102 (229)

The hallmarks of dietary intervention-resilient gut microbiome

npj Biofilms and Microbiomes, 2022
Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko, Vera E. Odintsova, Anastasia Revel-Muroz, Alexander V. Tyakht   +3 more
doaj   +1 more source

Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment

Microorganisms, 2022
Gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide [...]
Boris Shaskolskiy, Ilya Kandinov, Ekaterina Dementieva, Dmitry Gryadunov   +3 more
doaj   +1 more source

Large-Scale CRISPR Screen of LDLR Pathogenic Variants

Research, 2023
Familial hypercholesterolemia (FH) is a frequently occurring genetic disorder that is linked to early-onset cardiovascular disease. If left untreated, patients with this condition can develop severe cardiovascular complications.
Mengjing Li, Lerong Ma, Yiwu Chen, Jianing Li, Yanbing Wang, Wenni You, Hongming Yuan, Xiaochun Tang, Hongsheng Ouyang, Daxin Pang   +9 more
doaj   +1 more source

Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption

Nature Communications, 2022
CRISPR-Cas12f nucleases can be effectively packaged into AAVs for gene therapy, but a systematic evaluation of editing outcomes is lacking. Here the authors perform a comprehensive assessment of 4 Cas12f proteins and compare to Cas9 and two Cas12a ...
Changchang Xin, Jianhang Yin, Shaopeng Yuan, Liqiong Ou, Mengzhu Liu, Weiwei Zhang, Jiazhi Hu   +6 more
doaj   +1 more source

Differentially activated B cells develop regulatory phenotype and show varying immunosuppressive features: a comparative study

Frontiers in Immunology, 2023
Regulatory B lymphocytes (Bregs) are B cells with well-pronounced immunosuppressive properties, allowing them to suppress the activity of effector cells.
Elina A. Zheremyan, Alina S. Ustiugova, Aksinya N. Uvarova, Nina M. Karamushka, Ekaterina M. Stasevich, Violetta S. Gogoleva, Apollinariya V. Bogolyubova, Nikita A. Mitkin, Dmitry V. Kuprash, Dmitry V. Kuprash, Kirill V. Korneev, Kirill V. Korneev   +11 more
doaj   +1 more source

Cell Surface-Expressed GPI-Anchored Peptides from the CHR Domain of gp41 Are Potent Inhibitors of HIV-1 Fusion

Proceedings, 2020
Current antiretroviral therapy efficiently suppresses viral replication but cannot eliminate latent HIV reservoirs. Moreover, the associated high costs, side effects, and drug resistance have stimulated a need for the development of alternative methods ...
Aleksandra Maslennikova, Dmitriy Komkov, Anastasia Zotova, Dmitriy Mazurov   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

PtWAVE: a high-sensitive deconvolution software of sequencing trace for the detection of large indels in genome editing

BMC Bioinformatics
Background Tracking of Insertions and DEletions (TIDE) analysis, which computationally deconvolves capillary sequencing data derived from the DNA of bulk or clonal cell populations to estimate the efficiency of targeted mutagenesis by programmable ...
Kazuki Nakamae, Saya Ide, Nagaki Ohnuki, Yoshiko Nakagawa, Keisuke Okuhara, Hidemasa Bono   +5 more
doaj   +1 more source

Methodological landscape in the field of integration site identification of retroviruses and retroviral vectors

Frontiers in Bioengineering and Biotechnology
Detailed mapping of viral vector integration sites, including retroviral and particularly lentiviral vectors, is critical for assessing their safety in preclinical and clinical studies.
Konstantin Kochergin-Nikitsky, Alexander Lavrov, Svetlana Smirnikhina   +2 more
doaj   +1 more source

Whole genome MBD-seq and RRBS analyses reveal that hypermethylation of gastrointestinal hormone receptors is associated with gastric carcinogenesis

Experimental and Molecular Medicine, 2018
Stomach cancer: DNA methylation of hormone receptor genes A sequencing study reveals abnormal changes to DNA that set the stage for stomach cancer development.
Hee-Jin Kim, Tae-Wook Kang, Keeok Haam, Mirang Kim, Seon-Kyu Kim, Seon-Young Kim, Sang-Il Lee, Kyu-Sang Song, Hyun-Yong Jeong, Yong Sung Kim   +9 more
doaj   +1 more source