Results 21 to 30 of about 1,632,775 (273)
Peroxiredoxins—The Underrated Actors during Virus-Induced Oxidative Stress
Antioxidants, 2021 Enhanced production of reactive oxygen species (ROS) triggered by various stimuli, including viral infections, has attributed much attention in the past years. It has been shown that different viruses that cause acute or chronic diseases induce oxidative
Inna L. Karpenko +4 more
doaj +1 more source
Lipid-Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Components
Molecular Pharmaceutics, 2022 Gene editing mediated by CRISPR/Cas9 systems is due to become a beneficial therapeutic option for treating genetic diseases and some cancers. However, there are challenges in delivering CRISPR components which necessitate sophisticated delivery systems ...
Pardis Kazemian +5 more
semanticscholar +1 more source
Transcription shapes DNA replication initiation to preserve genome integrity
Genome Biology, 2021 Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu +10 more
doaj +1 more source
Gene editing CRISPR/Cas9 system for producing cows with hypoallergenic milk on the background of a beta-lactoglobulin gene knockout [PDF]
E3S Web of Conferences, 2020 Beta-lactoglobulin is the main allergen of cow’s milk. Modern approaches to reducing the allergenicity of milk require significant costs for its fermentation. An alternative approach could be the creation of productive breeds with a knockout for the gene
Silaeva Yulia Yu. +4 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2020 Based on engineered or bacterial nucleases, the development of genome editing technologies has opened up the possibility of directly targeting and modifying genomic sequences in almost all eukaryotic cells.
Hongyi Li +5 more
semanticscholar +1 more source
CRISPR SWAPnDROP -- A multifunctional system for genome editing and large-scale interspecies gene transfer [PDF]
, 2021 The need for diverse chromosomal modifications in biotechnology, synthetic biology and basic research requires the development of new technologies. With CRISPR SWAPnDROP, we extend the limits of genome editing to large-scale in-vivo DNA transfer between bacterial species.
arxiv +1 more source
Scientific Reports, 2021 Transforming growth factor beta (TGF-β) is the main cytokine responsible for the induction of the epithelial-mesenchymal transition of breast cancer cells, which is a hallmark of tumor transformation to the metastatic phenotype.
Alisa M. Gorbacheva +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Genome editing technologies enable the permanent repair of disease-causing genetic mutations. However, the application of this technology has been limited by the technical challenge of achieving safe, effective, and specific in vivo delivery
Min Qiu +10 more
semanticscholar +1 more source
BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]
, 2016 Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien +7 more
core +2 more sources
De Novo Transcriptome Profiling of Brain Tissue from the Annual Killifish Nothobranchius guentheri
Life, 2021 Nothobranchius is a genus of small annual killifish found in Africa. Due to the relatively short lifespan, as well as easy breeding and care, Nothobranchius fish are becoming widely used as a vertebrate model system. Studying the genome and transcriptome
Zulfiia G. Guvatova +14 more
doaj +1 more source