Results 51 to 60 of about 1,632,775 (273)
GENT2: an updated gene expression database for normal and tumor tissues
BMC Medical Genomics, 2019 Background Gene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene ...
Seung-Jin Park +3 more
doaj +1 more source
CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
Nucleic Acids Res., 2018 CRISPOR.org is a web tool for genome editing experiments with the CRISPR–Cas9 system. It finds guide RNAs in an input sequence and ranks them according to different scores that evaluate potential off-targets in the genome of interest and predict on ...
J. Concordet, M. Haeussler
semanticscholar +1 more source
Genome editing around the globe: An update on policies and perceptions
Plant Physiology, 2022 A decade ago, the CRISPR/Cas system has been adapted for genome editing. Since then, hundreds of organisms have been altered using genome editing and discussions were raised on the regulatory status of genome edited organisms esp. crops.
T. Sprink, R. Wilhelm, F. Hartung
semanticscholar +1 more source
Genome Editing for CNS Disorders [PDF]
Frontiers in Neuroscience, 2020 Central nervous system (CNS) disorders have a social and economic burden on modern societies, and the development of effective therapies is urgently required. Gene editing may prevent or cure a disease by inducing genetic changes at endogenous loci. Genome editing includes not only the insertion, deletion or replacement of nucleotides, but also the ...
Fábio Duarte +3 more
openaire +5 more sources
Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. [PDF]
, 2017 Precise genetic modifications in model animals are essential for biomedical research. Here, we report a programmable "base editing" system to induce precise base conversion with high efficiency in zebrafish. Using cytidine deaminase fused to Cas9 nickase,
Bai, Haipeng +7 more
core +1 more source
CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy
Science Advances, 2020 CRISPR lipid nanoparticles promote in vivo therapeutic genome editing in two aggressive cancer mouse models. Harnessing CRISPR-Cas9 technology for cancer therapeutics has been hampered by low editing efficiency in tumors and potential toxicity of ...
Daniel Rosenblum +11 more
semanticscholar +1 more source
Genome Editing for Sustainable Agriculture in Africa
Frontiers in Genome Editing, 2022 Sustainable intensification of agriculture in Africa is essential for accomplishing food and nutritional security and addressing the rising concerns of climate change.
L. Tripathi +7 more
semanticscholar +1 more source
Give CRISPR a chance : the GeneSprout Initiative [PDF]
, 2020 Did you know that a group of early-career researchers launched an initiative enabling open dialog on new plant breeding techniques, such as genome editing?
Boer, Damian +8 more
core +2 more sources
Attention-based Multi-task Learning for Base Editor Outcome Prediction [PDF]
arXiv, 2023 Human genetic diseases often arise from point mutations, emphasizing the critical need for precise genome editing techniques. Among these, base editing stands out as it allows targeted alterations at the single nucleotide level. However, its clinical application is hindered by low editing efficiency and unintended mutations, necessitating extensive ...
arxiv +1 more source
Antibiotic Resistance in Neisseria gonorrhoeae: Challenges in Research and Treatment
Microorganisms, 2022 Gonococcal infection caused by the Gram-negative bacteria Neisseria gonorrhoeae is one of the most common sexually transmitted infections (STIs) worldwide [...]
Boris Shaskolskiy +3 more
doaj +1 more source