Results 111 to 120 of about 5,201,388 (369)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1) provides insights into genome evolution

Nature Biotechnology, 2015
Gossypium hirsutum has proven difficult to sequence owing to its complex allotetraploid (AtDt) genome. Here we produce a draft genome using 181-fold paired-end sequences assisted by fivefold BAC-to-BAC sequences and a high-resolution genetic map.
Fuguang Li, Guangyi Fan, Cai-rui Lu, G. Xiao, Changsong Zou, R. Kohel, Zhiying Ma, Haihong Shang, Xiongfeng Ma, Jianyong Wu, Xinming Liang, Gai Huang, R. Percy, Kun Liu, Weihua Yang, Wenbin Chen, X. Du, Chengcheng Shi, You-lu Yuan, W. Ye, Xin Liu, Xueyang Zhang, Weiqing Liu, Hengling Wei, Shoujun Wei, Guodong Huang, Xianlong Zhang, Shuijin Zhu, He Zhang, F. Sun, Xingfen Wang, Jie Liang, Jiahao Wang, Qiang He, Leihuan Huang, Jun Wang, Jinjie Cui, G. Song, Kunbo Wang, Xun Xu, John Z. Yu, Yuxian Zhu, Shuxun Yu   +42 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts

Nature Communications, 2016
Catfish represent 12% of teleost or 6.3% of all vertebrate species, and are of enormous economic value. Here we report a high-quality reference genome sequence of channel catfish (Ictalurus punctatus), the major aquaculture species in the US.
Zhanjiang Liu, Shikai Liu, Jun Yao, Lisui Bao, Jiaren Zhang, Yun Li, Chen Jiang, Luyang Sun, Ruijia Wang, Yu Zhang, Tao Zhou, Qifan Zeng, Qiang Fu, Sen Gao, Ning Li, S. Koren, Yanliang Jiang, A. Zimin, Peng Xu, A. Phillippy, X. Geng, Lin Song, Fanyue Sun, Chao Li, Xiaozhu Wang, Ailu Chen, Yulin Jin, Zihao Yuan, Yujia Yang, Suxu Tan, E. Peatman, Jianguo Lu, Zhenkui Qin, R. Dunham, Zhaoxia Li, T. Sonstegard, Jianbin Feng, R. Danzmann, Steven G. Schroeder, B. Scheffler, M. Duke, Linda Ballard, H. Kucuktas, L. Kaltenboeck, Haixia Liu, J. Armbruster, Yangjie Xie, M. L. Kirby, Yiying Tian, M. Flanagan, W. Mu, G. Waldbieser   +51 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Discovery and genotyping of structural variation from long-read haploid genome sequence data

Genome Research, 2017
In an effort to more fully understand the full spectrum of human genetic variation, we generated deep single-molecule, real-time (SMRT) sequencing data from two haploid human genomes.
J. Huddleston, Mark J. P. Chaisson, K. M. Steinberg, W. Warren, Kendra Hoekzema, David S. Gordon, Tina A. Graves-Lindsay, Katherine M. Munson, Zev N. Kronenberg, Laura Vives, P. Peluso, Matthew Boitano, C. Chin, J. Korlach, R. Wilson, E. Eichler   +15 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Deletion of all Cochliobolus heterostrophus Monofunctional Catalase-Encoding Genes Reveals a Role for One in Sensitivity to Oxidative Stress but None with a Role in Virulence

Molecular Plant-Microbe Interactions, 2003
The genome of the maize pathogen Cochliobolus heterostrophus encodes three unlinked monofunctional catalase-encoding (CAT) genes that singly or in combination could offer protection against the harmful effects of oxidative stress.
Barbara Robbertse, O. C. Yoder, Anita Nguyen, Conrad L. Schoch, B. Gillian Turgeon   +4 more
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Genome sequencing and annotation of Stenotrophomonas sp. SAM8

Genomics Data, 2015
We report draft genome sequence of Stenotrophomonas sp. strain SAM8, isolated from environmental water. The draft genome size is 3,665,538 bp with a G + C content of 67.2% and contains 6 rRNA sequence (single copies of 5S, 16S & 23S rRNA).
Samy Selim, Sherif Hassan, Nashwa Hagagy
doaj   +1 more source