Results 1 to 10 of about 4,923,579 (336)

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Nature Medicine, 2020
Tumor protein p53 (TP53) is the most frequently mutated gene in cancer1,2. In patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease3,4, rapid transformation to acute myeloid leukemia (AML)5, resistance to ...
Elsa Bernard, Yasuhito Nannya, Robert P. Hasserjian, Sean M. Devlin, Heinz Tuechler, Juan S. Medina-Martínez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max F. Levine, Juan E. Arango, Yangyu Zhou, Françesc Solé, Catherine Cargo, Detlef Haase, Maria Creignou, Ulrich Germing, Yanming Zhang, Gunes Gundem, Araxe Sarian, Arjan A. van de Loosdrecht, Martin Jädersten, Magnus Tobiasson, Olivier Kosmider, Matilde Y. Follo, Felicitas Thol, Ronald Feitosa Pinheiro, Valeria Santini, Ιoannis Kotsianidis, Jacqueline Boultwood, Fábio Pires de Souza Santos, Julie Schanz, Senji Kasahara, Takayuki Ishikawa, Hisashi Tsurumi, Akifumi Takaori‐Kondo, Toru Kiguchi, Chantana Polprasert, John M. Bennett, Virginia M. Klimek, Michael R. Savona, Monika Beličková, Christina Ganster, Laura Palomo, Guillermo Sanz, Lionel Adès, Matteo Giovanni Della Porta, Harold K. Elias, Alexandra Smith, Yesenia Werner, Minal Patel, Agnès Viale, Katelynd Vanness, Donna Neuberg, Kristen E. Stevenson, Kamal Menghrajani, Kelly L. Bolton, Pierre Fenaux, Andrea Pellagatti, Uwe Platzbecker, Michael Heuser, Peter Valent, Shigeru Chiba, Yasushi Miyazaki, Carlo Finelli, Maria Teresa Voso, Lee‐Yung Shih, Michaëla Fontenay, Joop H. Jansen, José Cervera, Yoshiko Atsuta, Norbert Gattermann, Benjamin L. Ebert, Rafael Bejar, Peter L. Greenberg, Mario Cazzola, Eva Hellström-Lindberg, Seishi Ogawa, Elli Papaemmanuil   +79 more
openalex   +3 more sources

TIF1 Proteins in Genome Stability and Cancer [PDF]

Cancers, 2020
Genomic instability is a hallmark of cancer cells which results in excessive DNA damage. To counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to rapidly sense DNA damage and promote its repair whilst halting cell cycle ...
Roisin McAvera, Lisa Crawford
openalex   +2 more sources

Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability [PDF]

Scientific Reports, 2020
Genomic destabilisation is associated with the induction of mutations, including those in cancer-driver genes, and subsequent clonal evolution of cells with abrogated defence systems.
Yusuke Matsuno, Yuko Atsumi, Md. Alauddin, Md Masud Rana, Haruka Fujimori, Mai Hyodo, Atsuhiro Shimizu, Tomoki Ikuta, Hiroko Tani, Hidetaka Torigoe, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Michio Komai, Hitoshi Shirakawa, Kenichi Yoshioka   +14 more
openalex   +2 more sources

RIF1 promotes replication fork protection and efficient restart to maintain genome stability [PDF]

Nature Communications, 2019
Homologous recombination (HR) and Fanconi Anemia (FA) pathway proteins in addition to their DNA repair functions, limit nuclease-mediated processing of stalled replication forks.
Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A.T.M. van Vugt, Arnab Ray Chaudhuri   +9 more
openalex   +2 more sources

INO80 regulates promoter-associated R-loops to coordinate transcription and maintain genome stability in embryonic stem cells. [PDF]

Biol Res
Lim H, Kwon O, La H, Lee H, Lee H, Do JT, Song H, Choi Y, Hong K.   +8 more
europepmc   +2 more sources

Human topoisomerases and their roles in genome stability and organization

Nature reviews. Molecular cell biology, 2022
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A and TOP3B) topoisomerases.
Y. Pommier, A. Nussenzweig, S. Takeda, C. Austin   +3 more
semanticscholar   +1 more source

R-loop-dependent promoter-proximal termination ensures genome stability

Nature, 2023
The proper regulation of transcription is essential for maintaining genome integrity and executing other downstream cellular functions^ 1 , 2 . Here we identify a stable association between the genome-stability regulator sensor of single-stranded DNA ...
Congling Xu, Chengyu Li, Jiwei Chen, Y. Xiong, Zhibin Qiao, Pengyu Fan, Conghui Li, Shuangyu Ma, Jin Liu, Aixia Song, Bolin Tao, Tao Xu, Wei Xu, Y. Chi, J. Xue, Pu Wang, D. Ye, Hongzhou Gu, Peng Zhang, Qiong Wang, Ruijing Xiao, Jingdong Cheng, Hai Zheng, Xiaoli Yu, Zhen Zhang, Jiong Wu, Kaiwei Liang, Yan-Jun Liu, Huasong Lu, F. X. Chen   +29 more
semanticscholar   +1 more source

BAP1 as a guardian of genome stability: implications in human cancer

Experimental and Molecular Medicine, 2023
BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide array of biological activities. Studies in which advanced sequencing technologies were used have uncovered a link between BAP1 and human cancer.
Jongbum Kwon, Daye Lee, Shin-Ai Lee
semanticscholar   +1 more source

PARP1 associates with R-loops to promote their resolution and genome stability

Nucleic Acids Research, 2023
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution.
Natalie Laspata, Parminder Kaur, Sofiane Y Mersaoui, D. Muoio, Z. Liu, Maxwell Bannister, Hai Dang Nguyen, C. Curry, J. Pascal, G. Poirier, Hong Wang, J. Masson, Elise Fouquerel   +12 more
semanticscholar   +1 more source

Centromere: A Trojan horse for genome stability.

DNA Repair, 2023
Centromeres play a key role in the maintenance of genome stability to prevent carcinogenesis and diseases. They are specialized chromosome loci essential to ensure faithful transmission of genomic information across cell generations by mediating the ...
Andrea Scelfo, D. Fachinetti
semanticscholar   +1 more source