Results 11 to 20 of about 4,923,579 (336)
Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability.
Trends in Genetics, 2021 Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability ...
Francesca Mattiroli, L. Penengo
semanticscholar +1 more source
Walking a tightrope: The complex balancing act of R-loops in genome stability.
Molecules and Cells, 2022 Although transcription is an essential cellular process, it is paradoxically also a well-recognized cause of genomic instability. R-loops, non-B DNA structures formed when nascent RNA hybridizes to DNA to displace the non-template strand as single ...
Joshua R. Brickner +2 more
semanticscholar +1 more source
Nature Communications, 2021 ADAR1 is involved in adenosine-to-inosine RNA editing. The cytoplasmic ADAR1p150 edits 3’UTR double-stranded RNAs and thereby suppresses induction of interferons.
Yusuke Shiromoto +4 more
semanticscholar +1 more source
Echoed induction of nucleotide variants and chromosomal structural variants in cancer cells
Scientific Reports, 2022 Generally, the number of single-nucleotide variants (SNVs) in somatic cells increases with age, which is expected for replication errors. The number of SNVs in cancer cells, however, is often much higher than that in somatic cells, raising the question ...
Yusuke Matsuno +4 more
doaj +1 more source
eLife, 2023 Arrested replication forks, when restarted by homologous recombination, result in error-prone DNA syntheses and non-allelic homologous recombination. Fission yeast RTS1 is a model fork barrier used to probe mechanisms of recombination-dependent restart ...
Alice M Budden +6 more
doaj +1 more source
DEAD-Box RNA Helicases and Genome Stability
Genes, 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome ...
M. Cargill +2 more
semanticscholar +1 more source
DNA–protein crosslink proteases in genome stability
Communications Biology, 2021 Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination.
Annamaria Ruggiano, Kristijan Ramadan
semanticscholar +1 more source
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability.
DNA Repair, 2022 Histone Post-Translational Modifications (PTMs) play fundamental roles in mediating DNA-related processes such as transcription, replication and repair. The histone mark H3K36me3 and its associated methyltransferase SETD2 (Set2 in yeast) are archetypical
Asmita Sharda, T. Humphrey
semanticscholar +1 more source
HSP70 and Genomic Stability [PDF]
Cell Cycle, 2004 The 70 kDa heat shock proteins (HSP70s) were initially identified by their elevated expression following hyperthermic cell stress, however, these highly conserved proteins also protect critical cellular functions from a wider range of important environmental and physiological stresses.
Tej K, Pandita +2 more
openaire +2 more sources
CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
Nature Communications, 2021 CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-Cas2 ...
Katerina Zabrady +4 more
doaj +1 more source