Results 21 to 30 of about 4,923,579 (336)
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability
Frontiers in Cell and Developmental Biology, 2021 DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate.
C. Rinaldi +3 more
semanticscholar +1 more source
Replication dynamics of recombination-dependent replication forks
Nature Communications, 2021 Replication forks that are stalled at obstacles on the DNA template can be restarted by homologous recombination. Here, the authors show replication dynamics during homologous recombination-dependent replication fork restart by combining polymerase usage
Karel Naiman +5 more
doaj +1 more source
eLife, 2021 The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using single-molecule tracking in live fission yeast to investigate Smc5/6 chromatin association, we show ...
Thomas J Etheridge +10 more
doaj +1 more source
Role of Transposable Elements in Genome Stability: Implications for Health and Disease
International Journal of Molecular Sciences, 2022 Most living organisms have in their genome a sizable proportion of DNA sequences capable of mobilization; these sequences are commonly referred to as transposons, transposable elements (TEs), or jumping genes.
Audesh Bhat +9 more
semanticscholar +1 more source
SIRT7: a sentinel of genome stability
Open Biology, 2021 SIRT7 is a class III histone deacetylase that belongs to the sirtuin family. The past two decades have seen numerous breakthroughs in terms of understanding SIRT7 biological function. We now know that this enzyme is involved in diverse cellular processes,
Ming Tang +3 more
semanticscholar +1 more source
Hypoxia stabilizes SETDB1 to maintain genome stability
Nucleic Acids Research, 2023 Abstract Von Hippel–Lindau (VHL) is a tumor suppressor that functions as the substrate recognition subunit of the CRL2VHL E3 complex. While substrates of VHL have been identified, its tumor suppressive role remains to be fully understood.
Sungryul Park +14 more
openaire +2 more sources
Inhibition of MRN activity by a telomere protein motif
Nature Communications, 2021 Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus.
Freddy Khayat +11 more
doaj +1 more source
Chromium and genomic stability [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012 Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential.
Sandra S, Wise, John Pierce, Wise
openaire +2 more sources
Nature Communications, 2021 Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons.
Min-Min Lou +21 more
semanticscholar +1 more source
CST in maintaining genome stability: Beyond telomeres.
DNA Repair, 2021 The human CST (CTC1-STN1-TEN1) complex is an RPA-like single-stranded DNA binding protein complex. While its telomeric functions have been well investigated, numerous studies have revealed that hCST also plays important roles in maintaining genome ...
Xinxing Lyu, Pau Biak Sang, Weihang Chai
semanticscholar +1 more source