Results 301 to 310 of about 4,923,579 (336)

Cytoplasmic localization of ribonucleotide reductase is essential for genome stability

Andreadis C, Salguero I, Kearsey SE.
europepmc   +1 more source

Donor transcription suppresses D-loops in cis and promotes genome stability

Djeghmoum Y, Piazza A.
europepmc   +1 more source

Genome stability.

Seminars in Cell & Developmental Biology, 2021
F. Esashi
semanticscholar   +4 more sources

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Genome stability in Drosophila: Mismatch repair and genome stability

Genome Stability, 2021
T. Negishi
semanticscholar   +2 more sources

Epigenetics and genome stability

Mammalian Genome, 2020
Maintaining genome stability is essential to an organism's health and survival. Breakdown of the mechanisms protecting the genome and the resulting genome instability are an important aspect of the aging process and have been linked to diseases such as cancer. Thus, a large network of interconnected pathways is responsible for ensuring genome integrity
Justina X. Feng, N. C. Riddle
semanticscholar   +3 more sources

Genome stability from the perspective of telomere length.

Trends in Genetics, 2023
Telomeres and their associated proteins protect the ends of chromosomes to maintain genome stability. Telomeres undergo progressive shortening with each cell division in mammalian somatic cells without telomerase, resulting in genome instability.
Xinyi Lu, Lin Liu
semanticscholar   +1 more source

E2 Enzymes in Genome Stability: Pulling the Strings Behind the Scenes.

Trends in Cell Biology, 2021
Ubiquitin and ubiquitin-like proteins (UBLs) function as critical post-translational modifiers in the maintenance of genome stability. Ubiquitin/UBL-conjugating enzymes (E2s) are responsible, as part of a wider enzymatic cascade, for transferring single ...
Hugh C. Osborne, E. Irving, J. Forment, C. K. Schmidt   +3 more
semanticscholar   +1 more source

Genomic stability in reprogramming

Current Opinion in Genetics & Development, 2012
The genetic stability of induced pluripotent stem (iPS) cells has a significant impact on their potential use in regenerative medicine and basic research. Analysis of the genomic integrity of iPS cells suggests a tendency to develop aberrations ranging from whole chromosome trisomies to single nucleotide mutations. Furthermore, fluctuations in telomere
Daniel, Ronen, Nissim, Benvenisty
openaire   +2 more sources

Telomere maintenance and genome stability

Genome Stability, 2021
Telomeres are the end caps of linear chromosomes that help to ensure genomic stability. Due to inadequacies of replicative polymerases to synthesize the extreme ends of lagging strand DNA, telomere length in adult, somatic cells decreases slightly with ...
W. Hernandez-Sanchez, Mengyuan Xu, Derek J. Taylor   +2 more
semanticscholar   +1 more source

Chromosome segregation and genomic stability

Current Opinion in Genetics & Development, 2004
The acquisition of genomic instability is a crucial step in the development of human cancer. Genomic instability has multiple causes of which chromosomal instability (CIN) and microsatellite instability (MIN) have received the most attention. Whereas the connection between a MIN phenotype and cancer is now proven, the argument that CIN causes cancer ...
Viji M, Draviam, Stephanie, Xie, Peter K, Sorger   +2 more
openaire   +2 more sources