Results 31 to 40 of about 4,923,579 (336)
Royal Society Open Science, 2021 Unlike bacteria, mammalian cells need to complete DNA replication before segregating their chromosomes for the maintenance of genome integrity. Thus, cells have evolved efficient pathways to restore stalled and/or collapsed replication forks during S ...
Camelia Mocanu, Kok-Lung Chan
doaj +1 more source
The Ubiquitin Proteasome System in Genome Stability and Cancer
Cancers, 2021 Simple Summary Genomic instability is a major driving force of tumour development and evolution. Cells have developed sophisticated regulatory systems to preserve the stability of the genome and defects in these mechanisms can lead to the acquisition of ...
Jonathan H. Morgan, L. Crawford
semanticscholar +1 more source
Genes and Environment, 2021 Background Stress response is mediated by the transcription of stress-responsive genes. The F-box motif protein Saf1p is involved in SCF-E3 ligase mediated degradation of the adenine deaminase, Aah1p upon nutrient stress.
Meenu Sharma +2 more
doaj +1 more source
Mechanisms of genome stability maintenance during cell division.
DNA Repair, 2021 During mitosis, chromosomes undergo extensive structural changes resulting in the formation of compact cylindrical bodies and in the termination of the bulk of DNA-dependent metabolic activities.
Mara de Marco Zompit, M. Stucki
semanticscholar +1 more source
A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
Nature Communications, 2019 Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs).
William H. Gittens +5 more
doaj +1 more source
Nature Communications, 2019 The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones +4 more
doaj +1 more source
Genome Stability Requires p53 [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 It is now clear that functional p53 is critical to protect the genome from alterations that lead to tumorigenesis. However, with the myriad of cellular stresses and pathways linked to p53 activation, much remains unknown about how p53 maintains genome stability and the proteins involved. The current understanding of the multiple ways p53 contributes to
openaire +2 more sources
Genome stability versus transcript diversity [PDF]
DNA Repair, 2016 Our genome is protected from the introduction of mutations by high fidelity replication and an extensive network of DNA damage response and repair mechanisms. However, the expression of our genome, via RNA and protein synthesis, allows for more diversity in translating genetic information.
Brian, Magnuson +2 more
openaire +2 more sources
ARID1A mutation and genomic stability [PDF]
Molecular & Cellular Oncology, 2020 We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated ...
Timothy Nacarelli +3 more
openaire +3 more sources
Nature Communications, 2018 Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA ...
Ankana Tiwari +2 more
doaj +1 more source