Results 41 to 50 of about 4,923,579 (336)

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

Nature Communications, 2016
Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy, Stuart L. Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W. Oliver, Laurence H. Pearl, Keith W. Caldecott   +7 more
doaj   +1 more source

Genomic stability of Self-inactivating Rabies [PDF]

eLife, 2020
Abstract Transsynaptic viral vectors provide means to gain genetic access to neurons based on synaptic connectivity and are essential tools for the dissection of neural circuit function. Among them, the retrograde monosynaptic ΔG-Rabies has been widely used in neuroscience research.
Ernesto Ciabatti, Ana González-Rueda, Daniel de Malmazet, Hassal Lee, Fabio Morgese, Marco Tripodi   +5 more
openaire   +3 more sources

Immune Checkpoints in Viral Infections

Viruses, 2020
As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system ...
Huiming Cai, Ge Liu, Jianfeng Zhong, Kai Zheng, Haitao Xiao, Chenyang Li, Xun Song, Ying Li, Chenshu Xu, Haiqiang Wu, Zhendan He, Qinchang Zhu   +11 more
doaj   +1 more source

Cdc14 phosphatase counteracts Cdk-dependent Dna2 phosphorylation to inhibit resection during recombinational DNA repair

Nature Communications, 2023
Cyclin-dependent kinase (Cdk) stimulates resection of DNA double-strand breaks ends to generate single-stranded DNA (ssDNA) needed for recombinational DNA repair.
Adrián Campos, Facundo Ramos, Lydia Iglesias, Celia Delgado, Eva Merino, Antonio Esperilla-Muñoz, Jaime Correa-Bordes, Andrés Clemente-Blanco   +7 more
doaj   +1 more source

RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability. [PDF]

Nucleic Acids Res
Provasek VE, Bacolla A, Rangaswamy S, Kodavati M, Mitra J, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML.   +14 more
europepmc   +3 more sources

Genomic stability and tumorigenesis

Seminars in Cancer Biology, 2005
Cancer research needs to explain the observed incidence of cancer. Many factors determine this process, including: the number of susceptible cells in the tissue of origin; the number of normal cell divisions through which susceptible cells pass in normal development and turnover; the number of cell divisions during tumorigenesis; the selective ...
Sieber, O, Heinimann, K, Tomlinson, I
openaire   +2 more sources

Maintenance of Genome Stability

Genomics, Proteomics & Bioinformatics, 2016
It was ever thought that genomic information is transmitted faithfully from generation to generation. But our current knowledge does not indicate that it is the case. For example, genomic variations can be generated from DNA replication infidelity and unequal chromosome segregation.
Jiadong Wang, Tomas Lindahl
openaire   +4 more sources

Prophase-Specific Perinuclear Actin Coordinates Centrosome Separation and Positioning to Ensure Accurate Chromosome Segregation

Cell Reports, 2020
Summary: Centrosome separation in late G2/ early prophase requires precise spatial coordination that is determined by a balance of forces promoting and antagonizing separation. The major effector of centrosome separation is the kinesin Eg5.
Tom Stiff, Fabio R. Echegaray-Iturra, Harry J. Pink, Alex Herbert, Constantino Carlos Reyes-Aldasoro, Helfrid Hochegger   +5 more
doaj   +1 more source

Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes

Nucleus, 2023
In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes.
Clare S.K. Lee, Matthias Weiβ, Stephan Hamperl   +2 more
doaj   +1 more source

USP7 Is a Master Regulator of Genome Stability

Frontiers in Cell and Developmental Biology, 2020
Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary drivers of tumor formation and cancer progression. These alterations can endow cells with a selective growth advantage, enabling cancers to evade cell death ...
Gabrielle J. Valles, I. Bezsonova, R. Woodgate, Nicholas W. Ashton   +3 more
semanticscholar   +1 more source