Results 201 to 210 of about 23,710,291 (301)

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Low-level contamination confounds population genomic analysis. [PDF]

G3 (Bethesda)
Ward AK, Scopel EFC, Shuman B, Momany M, Bensasson D.   +4 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Phenotypic and Genomic Analysis of <i>Pediococcus acidilactici</i> MBEL10321 with Potential Probiotic Properties. [PDF]

J Microbiol Biotechnol
Yoon JA, Ju MK, Lee CH, Ryu YJ, Jin YJ, Kim MD.   +5 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Rapid genomic analysis for early identification of complement abnormalities in adults with transplant-associated thrombotic microangiopathy. [PDF]

Hematol Transfus Cell Ther
Mariotti J, Bramanti S, Porcaro L, Ardissino G, Pagliari MT, Spena S, Cairo A, Griffini S, Sarina B, Marchelli D, Arbustini E, Urtis M, Tescari A, Santoro A, Peyvandi F, Cugno M.   +15 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Comparative genomic analysis of <i>Bacteroides fragilis</i> from intestinal and extra-intestinal sites. [PDF]

Microbiol Spectr
Oles RE, Carrillo Terrrazas M, Loomis LR, Zuffa S, Neal MJ, Hsu C-Y, Vasquez Ayala A, Tribelhorn C, Belda-Ferre P, Zhao J, Bryant M, Zemlin J, Young J, Dulai PS, Sandborn WJ, Sivagnanam M, Pride D, Zengler K, Dorrestein PC, Knight R, Chu H.   +20 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source