Results 11 to 20 of about 291,376 (305)

Cell Cycle Analysis of Candida albicans by Flow Cytometry

Bio-Protocol, 2023
The cell cycle is a vital process of cell division that is required to sustain life. Since faithful cell division is critical for the proper growth and development of an organism, the study of the cell cycle becomes a fundamental research objective ...
Shraddheya Patel, Satya Sahu, Narottam Acahrya   +2 more
doaj   +1 more source

Vaccines against candidiasis: Status, challenges and emerging opportunity

Frontiers in Cellular and Infection Microbiology, 2022
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals.
Satya Ranjan Sahu, Satya Ranjan Sahu, Swagata Bose, Swagata Bose, Manish Singh, Premlata Kumari, Premlata Kumari, Abinash Dutta, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Shraddheya Kumar Patel, Narottam Acharya   +12 more
doaj   +1 more source

MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs

Cells, 2022
DNA double-strand breaks (DSBs) are one of the most lethal types of DNA damage due to the fact that unrepaired or mis-repaired DSBs lead to genomic instability or chromosomal aberrations, thereby causing cell death or tumorigenesis.
Muddenahalli Srinivasa Sudhanva, Gurusamy Hariharasudhan, Semo Jun, Gwanwoo Seo, Radhakrishnan Kamalakannan, Hyun Hee Kim, Jung-Hee Lee   +6 more
doaj   +1 more source

CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis

Cells, 2022
CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. However,
Wonkyung Oh, Ting Ting Wu, Seo-Yeon Jeong, Ho Jin You, Jung-Hee Lee   +4 more
doaj   +1 more source

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. [PDF]

, 2020
Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers.
Axelrod, Joshua, Bapat, Jaidev, Delaney, Joe R, DeStefano, John W, Haghighiabyaneh, Mina, Harismendy, Olivier, Jones, Christian M, La Spada, Albert R, Ortell, Katherine K, Patel, Chandni B, Ramos-Zapatero, Maria, Schlaepfer, David D, Stupack, Dwayne G, Tancioni, Isabelle, Tanios, Ralph   +14 more
core   +1 more source

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

Scientific Reports, 2022
The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory “cytokine storm” (CS) plays a determinant role.
Laura Sanchez-Burgos, Gonzalo Gómez-López, Fátima Al-Shahrour, Oscar Fernandez-Capetillo   +3 more
doaj   +1 more source

DNMTs are required for delayed genome instability caused by radiation [PDF]

, 2012
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, RM, Armstrong, CA, Iyer, P, Jones, GD, Narayanan, D, Sandhu, J, Singh, R, Talbot, CJ, Talbot, CJ, Tufarelli, C, Tufarelli, C   +10 more
core   +2 more sources

Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1

Cell Death and Disease, 2022
The cell signaling factors EGFR, EphA2, and Ephexin1 are associated with lung and colorectal cancer and play an important role in tumorigenesis. Although the respective functional roles of EGFR and EphA2 are well known, interactions between these ...
Jeeho Kim, In-Youb Chang, Ho Jin You
doaj   +1 more source

Protocol for analysis of G2/M DNA synthesis in human cells

STAR Protocols, 2021
Summary: G2/M DNA synthesis (G-MiDS) can be observed in one in five G2/M cells in unperturbed conditions by immunofluorescence microscopy. However, little is known of the genomic sites undergoing G-MiDS.
Jianming Wang, Marco Saponaro
doaj   +1 more source

Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability [PDF]

, 2017
R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability.
Aguilera López, Andrés, Bayona Feliu, Aleix, Luna Varo, Rosa María, Pérez Calero, Carmen, Salas Armenteros, Irene, Tumini, Emanuela   +5 more
core   +1 more source