Results 11 to 20 of about 159,690 (243)
Vaccines against candidiasis: Status, challenges and emerging opportunity
Frontiers in Cellular and Infection Microbiology, 2022 Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals.
Satya Ranjan Sahu +12 more
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Cells, 2022 DNA double-strand breaks (DSBs) are one of the most lethal types of DNA damage due to the fact that unrepaired or mis-repaired DSBs lead to genomic instability or chromosomal aberrations, thereby causing cell death or tumorigenesis.
Muddenahalli Srinivasa Sudhanva +6 more
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CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis
Cells, 2022 CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. However,
Wonkyung Oh +4 more
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Scientific Reports, 2022 The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory “cytokine storm” (CS) plays a determinant role.
Laura Sanchez-Burgos +3 more
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Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1
Cell Death and Disease, 2022 The cell signaling factors EGFR, EphA2, and Ephexin1 are associated with lung and colorectal cancer and play an important role in tumorigenesis. Although the respective functional roles of EGFR and EphA2 are well known, interactions between these ...
Jeeho Kim, In-Youb Chang, Ho Jin You
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Protocol for analysis of G2/M DNA synthesis in human cells
STAR Protocols, 2021 Summary: G2/M DNA synthesis (G-MiDS) can be observed in one in five G2/M cells in unperturbed conditions by immunofluorescence microscopy. However, little is known of the genomic sites undergoing G-MiDS.
Jianming Wang, Marco Saponaro
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Cell Death and Disease, 2021 Abstrct Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. Here, we show that Ephexin1 is highly expressed in colorectal cancer (CRC) and lung cancer (LC) patient tissues ...
Jeeho Kim +6 more
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Transcription–Replication Coordination
Life, 2022 Transcription and replication are the two most essential processes that a cell does with its DNA: they allow cells to express the genomic content that is required for their functions and to create a perfect copy of this genomic information to pass on to ...
Marco Saponaro
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Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs
Molecular Oncology, 2011 Trying to kill cancer cells by generating DNA damage is by no means a new idea. Radiotherapy and genotoxic drugs are routinely used in cancer therapy.
Luis I. Toledo +2 more
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Lab-made 3D printed stoppers as high-throughput cell migration screening tool
SLAS Technology, 2022 Cell migration is a process that underlies the development and maintenance of multicellular organisms, with profound implications in various pathologies.
Silvina Acosta +4 more
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