Results 21 to 30 of about 159,690 (243)
SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer
BMC Cancer, 2022 Background Scavenger receptor class A member 3 (SCARA3) is decreased in prostate cancer and myeloma. However, functions of SCARA3 in various cancers remain unclear.
Jeeho Kim, Ho Jin You, Chakyung Youn
doaj +1 more source
Current Oncology, 2022 Genomic instability facilitates the evolution of cells, tissues, organs, and species. The progression of human malignancies can be regarded as the accumulation of genomic instability, which confers a high evolutionary potential for tumor cells to adapt ...
Xue Liu +11 more
doaj +1 more source
Genomic Instability in Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 One of the fundamental challenges facing the cell is to accurately copy its genetic material to daughter cells. When this process goes awry, genomic instability ensues in which genetic alterations ranging from nucleotide changes to chromosomal translocations and aneuploidy occur.
Tarek, Abbas +2 more
openaire +2 more sources
ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
Nature Communications, 2017 MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee +11 more
doaj +1 more source
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
doaj +1 more source
Clinical consequences of BRCA2 hypomorphism
npj Breast Cancer, 2021 The tumor suppressor FANCD1/BRCA2 is crucial for DNA homologous recombination repair (HRR). BRCA2 biallelic pathogenic variants result in a severe form of Fanconi anemia (FA) syndrome, whereas monoallelic pathogenic variants cause mainly hereditary ...
Laia Castells-Roca +17 more
doaj +1 more source
Mutation-Derived Long Noncoding RNA Signature Predicts Survival in Lung Adenocarcinoma
Frontiers in Oncology, 2022 BackgroundGenomic instability is one of the representative features of cancer evolution. Recent research has revealed that long noncoding RNAs (lncRNAs) play a critical role in maintaining genomic instability. Our work proposed a gene signature (GILncSig)
Longjun Yang +29 more
doaj +1 more source
A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells
Cell Reports, 2019 Summary: The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth ...
Teresa Olbrich +7 more
doaj +1 more source
Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2008 Increasing genomic instability is associated with aging in eukaryotes, but the connection between genomic instability and natural variation in life span is unknown. We have quantified chronological life span and loss-of-heterozygosity (LOH) in 11 natural
Hong Qin, Meng Lu, David S Goldfarb
doaj +1 more source
Cell, 2013 To whet your appetite for the special focus in next issue’s Leading Edge on Genomic Instability, we take a look at what’s new in the field of DNA repair. Ranging from network analyses of the proteins involved in mutagenic DNA repair to examination of single molecules taking part in homologous recombination, this Select probes the inner workings of a ...
openaire +1 more source