Results 21 to 30 of about 291,376 (305)

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Akt-mediated Ephexin1–Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation

Cell Death and Disease, 2021
Abstrct Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. Here, we show that Ephexin1 is highly expressed in colorectal cancer (CRC) and lung cancer (LC) patient tissues ...
Jeeho Kim, Young Jin Jeon, Sung-Chul Lim, Joohyun Ryu, Jung-Hee Lee, In-Youb Chang, Ho Jin You   +6 more
doaj   +1 more source

Transcription–Replication Coordination

Life, 2022
Transcription and replication are the two most essential processes that a cell does with its DNA: they allow cells to express the genomic content that is required for their functions and to create a perfect copy of this genomic information to pass on to ...
Marco Saponaro
doaj   +1 more source

Breast tumor copy number aberration phenotypes and genomic instability [PDF]

, 2006
Background Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g.
Jane Fridlyand, Antoine M Snijders, Bauke Ylstra, Hua Li, Adam Olshen, Richard Segraves, Shanaz Dairkee, Taku Tokuyasu, Britt Marie Ljung, Ajay N Jain, Jane McLennan, John Ziegler, Koei Chin, Sandy Devries, Heidi Feiler, Joe W Gray, Frederic Waldman, Daniel Pinkel, Donna G Albertson, DG Albertson, DP Cahill, Z Wang, J Bartkova, VG Gorgoulis, DM Feldser, JH Mao, E Hernando, DG Albertson, D Pinkel, AM Snijders, AM Snijders, LW Loo, AN Snijders, EA Rakha, EA Rakha, T van Wezel, G Jonsson, LF Wessels, R Scully, RH Wang, K Yoshida, S Staff, M Wei, T Beissbarth, E Berkovich, L Carrassa, S Ishida, R Iwanaga, Y Jiang, AE Kel, H Muller, S Polager, B Ren, R Vernell, M Markey, EP Black, P Zacharatos, PL Paris, MT Pickering, LS Michel, X Wang, II Ouspenski, D Cortez, L Smith, R Habedanck, JR Bischoff, M Olivier   +66 more
core   +2 more sources

Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs

Molecular Oncology, 2011
Trying to kill cancer cells by generating DNA damage is by no means a new idea. Radiotherapy and genotoxic drugs are routinely used in cancer therapy.
Luis I. Toledo, Matilde Murga, Oscar Fernandez‐Capetillo   +2 more
doaj   +1 more source

Lab-made 3D printed stoppers as high-throughput cell migration screening tool

SLAS Technology, 2022
Cell migration is a process that underlies the development and maintenance of multicellular organisms, with profound implications in various pathologies.
Silvina Acosta, Lucía Canclini, Carlos Galarraga, Cristian Justet, Diego Alem   +4 more
doaj   +1 more source

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. [PDF]

, 2016
The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer.
Bocek, Michael, Chédin, Frédéric, Cimprich, Karlene A, Crossley, Madzia P, Sanz, Lionel A, Sollier, Julie, Stork, Caroline Townsend, Swigut, Tomek   +7 more
core   +3 more sources

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis [PDF]

, 2014
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes.
Anderson, M, Bailey, P, Barbour, A, Bruxner, T, Campbell, P, Christ, A, Fink, J, Gotley, D, Grimmond, S, Harliwong, I, Hayward, N, Holmes, O, Hussey, D, Idrisoglu, S, Kazakoff, S, Krause, L, Lampe, G, Leonard, C, Loffler, K, Lord, R, Manning, S, Miller, D, Nancarrow, D, Newell, F, Nones, K, Nourbakhsh, E, Nourse, C, Patch, A, Pearson, J, Phillips, W, Quek, K, Quinn, M, Reid, L, Simpson, P, Smithers, B, Tang, Y, Waddell, N, Waddell, N, Watson, D, Wayte, N, Whiteman, D, Wilson, P, Wood, S, Xu, Q   +43 more
core   +4 more sources

SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer

BMC Cancer, 2022
Background Scavenger receptor class A member 3 (SCARA3) is decreased in prostate cancer and myeloma. However, functions of SCARA3 in various cancers remain unclear.
Jeeho Kim, Ho Jin You, Chakyung Youn
doaj   +1 more source

Patterns of genomic instability in gastric cancer: clinical implications and perspectives. [PDF]

, 2007
In gastric cancer (GC) the loss of genomic stability represents a key molecular step that occurs early in the carcinogenesis process and creates a permissive environment for the accumulation of genetic and epigenetic alterations in tumor suppressor genes
AGNESE, Valentina, BAZAN, Viviana, COLUCCI G, FALCHETTI M, LUPI R, OTTINI L, RIZZOLO P, RUSSO, Antonio   +7 more
core   +1 more source