Results 31 to 40 of about 291,376 (305)
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation
Life Science Alliance, 2021 This work reveals a novel function of WWP1 E3 ligase in the mono-ubiquitination of AMOTL2, which enables the binding and activation of LATS kinases upon contact inhibition.
Daehee Hwang +7 more
doaj +1 more source
Catastrophic chromosomal restructuring during genome elimination in plants. [PDF]
, 2015 Genome instability is associated with mitotic errors and cancer. This phenomenon can lead to deleterious rearrangements, but also genetic novelty, and many questions regarding its genesis, fate and evolutionary role remain unanswered.
Bradnam, Keith R +9 more
core +1 more source
Genomic instability and DNA replication defects in progeroid syndromes [PDF]
, 2018 Progeroid syndromes induced by mutations in lamin A or in its interactors – named progeroid laminopathies – are model systems for the dissection of the molecular pathways causing physio- logical and premature aging.
Chiara Merigliano +4 more
core +1 more source
Genomic Instability in Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 One of the fundamental challenges facing the cell is to accurately copy its genetic material to daughter cells. When this process goes awry, genomic instability ensues in which genetic alterations ranging from nucleotide changes to chromosomal translocations and aneuploidy occur.
Tarek, Abbas +2 more
openaire +2 more sources
ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
Nature Communications, 2017 MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee +11 more
doaj +1 more source
Current Oncology, 2022 Genomic instability facilitates the evolution of cells, tissues, organs, and species. The progression of human malignancies can be regarded as the accumulation of genomic instability, which confers a high evolutionary potential for tumor cells to adapt ...
Xue Liu +11 more
doaj +1 more source
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
doaj +1 more source
Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]
, 2020 Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak +4 more
core +1 more source
Histone Mutants Separate R Loop Formation from Genome Instability Induction [PDF]
, 2017 R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability.
Aguilera López, Andrés +5 more
core +1 more source
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]
, 2020 Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders.
Beleggia, Filippo +7 more
core +1 more source