Results 91 to 100 of about 1,069,336 (306)

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups [PDF]

, 2010
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents.
Marjo-Riitta Jarvelin, Martin Klingenspor, Heude, Barbara, Lévy-Marchal, C., Wichmann HE, Balkau, B, Hebebrand, J., Schürmann, A., Kiess, W., Fromme Tobias, Hartikainen, A.L., Rosskopf D, Erbel, R., Schulz N, Klingenspor Martin, Wichmann, H.-E., Schäfer H, Illig Thomas, Joeckel, Karl-Heinz, Fisher E, Johannes Hebebrand, Vogel, Carla I. G., Schulz, N, Jacques Weill, Hartikainen Anna-Liisa, Körner, A, Nöthen, MM, Krude Heiko, Borte, M, Scherag André, Froguel Philippe, Winfried Rief, Hinney A, Nöthen, M.M., Klingenspor, Martin, Hartikainen AL, Boeing Heiner, Schaefer, Helmut, Schulz, N., Rayner, Nigel W., Borte, Michael, Balkau, B., Rosskopf Dieter, Moebus, Susanne, Heinrich, Joachim, Harald Grallert, Hebebrand J, Heinrich, J., Thomas W Mühleisen, Rzehak, Peter, Klingenspor, M, Scherag S, Grallert, H., Hinney, A., Fromme, T., Vogel CI, Moebus, S, Rayner NW, Erbel, R, Dieter Rosskopf, Reinehr, T., Hartikainen, Anna-Liisa, Scherag A, Vogel, CIG, Eva Fisher, Jarvelin, Marjo-Riitta, Hartikainen, AL, Biebermann, Heike, Mühleisen TW, Vatin, V, Noethen, Markus M., Nigel W Rayner, Wichmann, H-E, Grallert H, Inga Prokopenko, Dina, C., Jarick Ivonne, Rief W, Vogel, CI, Mueller, Timo D., Prokopenko I, Berdel Dietrich, David Meyre, Berdel, D., Jarvelin, M.R., Hebebrand, Johannes, Borte Michael, Reinehr, T, Schulz Nadja, Grallert, Harald, Jarvelin, M-R, Vatin, Vincent, Joeckel, K-H, Schaefer, H, Meyre D, Jarvelin MR, Fisher Eva, Boes Tanja, Heude, B, Fisher, E, Levy-Marchal, Claire, Heiko Krude, Vogel, C.I.G., Borte M, McCarthy, MI, Koerner, Antje, Karl-Heinz Jöckel, McCarthy Mark I., Boeing H, Noethen, MM, Erbel, Raimund, Wichmann, HE, Heinrich, J, Illig T, Peter Rzehak, Jarvelin Marjo-Riitta, Mýhleisen TW, Grallert Harald, Thomas Illig, Weill, J, Levy-Marchal, C, Heude Barbara, Kovacs Peter, Jöckel, KH, Kovacs, P, Heude B, Prokopenko, Inga, Meyre, David, Rzehak Peter, Fromme, Tobias, Vogel Carla I. G., McCarthy, Mark I., Krude, H, Berdel, D, Kiess, W, Mühleisen Thomas W., Rief, W., Froguel P, Boeing, Heiner, Claire Levy-Marchal, McCarthy MI, Biebermann H, Illig, T, Mueller, TD, Christian Rimmbach, Scherag Susann, Tanja Boes, Carla I G Vogel, Vatin, V., Fisher, Eva, Heude, B., Prokopenko, I, Heike Biebermann, Reinehr Thomas, Hinney, A, Ivonne Jarick, Heiner Boeing, Christian Dina, Moebus, S., Delplanque J, Kovacs, P., Dina Christian, Fromme T, Illig, T., Weill, Jacques, Rosskopf, Dieter, Fisher, E., Reinehr, Thomas, Jöckel KH, Boes, T, Nadja Schulz, Kovacs, Peter, Moebus S, Schýrmann A, Muehleisen, TW, Heinrich Joachim, Raimund Erbel, Rosskopf, D., Prokopenko, I., Körner Antje, Scherag, Susann, Rimmbach, Christian, Dina C, Antje Körner, Koerner, A, Hebebrand, J, Scherag, S., Scherag, A, Rzehak, P., Thomas Reinehr, Rief, Winfried, Boeing, H, Reinehr T, Klingenspor M, Helmut Schäfer, Scherag, S, Schäfer, H, H-Erich Wichmann, Schäfer, H., Hebebrand Johannes, Meyre David, Rayner, N.W., Kiess, Wieland, Anke Hinney, Hinney Anke, Scherag, Andre, Meyre, D, Rosskopf, D, Hinney, Anke, Biebermann, H., Susanne Moebus, Körner A, Scherag, A., Levy-Marchal C, Müller, T.D., Delplanque, Jerome, Rief Winfried, Muehleisen, Thomas W., Müller TD, Krude, H., Rimmbach, C, Jöckel, K.-H., Rzehak P, Berdel D, Philippe Froguel, Biebermann, H, Wichmann, Heinz-Erich, Rief, W, Anna-Liisa Hartikainen, Barbara Heude, McCarthy, M.I., Jarvelin, MR, André Scherag, Jérôme Delplanque, Rayner, NW, Boes, T., Jarick I, Beverley Balkau, Rimmbach, C., Mühleisen, T.W., Mühleisen, TW, Vatin Vincent, Vincent Vatin, Hartikainen, A-L, Moebus Susanne, Schürmann, A, Delplanque, J, Michael Borte, Balkau, Beverley, Susann Scherag, Boes T, Balkau Beverley, Jarick, Ivonne, Boes, Tanja, Müller, TD, Prokopenko Inga, Borte, M., Annette Schürmann, Krude H, Berdel, Dietrich, Nöthen Markus M., Jarick, I, Müller Timo D., Schulz, Nadja, Wichmann H.-Erich, Dina, Christian, Dina, C, Mýller TD, Froguel, Philippe, Weill Jacques, Fromme, T, Rimmbach C, Grallert, H, Schuermann, Annette, Mark I McCarthy, Schäfer Helmut, Weill, J., Delplanque Jérôme, Rayner Nigel W., Kiess Wieland, Illig, Thomas, Timo D Müller, Joachim Heinrich, Balkau B, Vatin V, Tobias Fromme, Rzehak, P, Schürmann Annette, Kiess W, Körner, A., Nöthen MM, Levy-Marchal Claire, Kovacs P, Markus M Nöthen, Erbel Raimund, Wieland Kiess, Erbel R, Heinrich J, Dietrich Berdel, Klingenspor, M., Jarick, I., Schürmann A, Rimmbach Christian, Boeing, H., Froguel, P., Peter Kovacs, Krude, Heiko, Weill J, Schuermann, A, Delplanque, J., Jöckel Karl-Heinz, Biebermann Heike, Meyre, D., Froguel, P, Scherag, A., Dina, C., Hinney, A., Vatin, V., Scherag, S., Vogel, C.I.G., Müller, T.D., Grallert, H., Wichmann, H.-E., Balkau, B., Heude, B., Jarvelin, M.-R., Hartikainen, A.-L., Levy-Marchal, C., Weill, J., Delplanque, J., Körner, A., Kiess, W., Kovacs, P., Rayner, N.W., Prokopenko, I., McCarthy, M.I., Schäfer, H., Jarick, I., Boeing, H., Fisher, E., Reinehr, T., Heinrich, J., Rzehak, P., Berdel, D., Borte, M., Biebermann, H., Krude, H., Rosskopf, D., Rimmbach, C., Rief, W., Fromme, T., Klingenspor, M., Schürmann, A., Schulz, N., Nöthen, M.M., Mühleisen, T.W., Erbel, R., Jöckel, K.-H., Moebus, S., Boes, T., Illig, T., Froguel, P., Hebebrand, J., Meyre, D.   +314 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Femtosecond laser enabled keratoplasty for advanced keratoconus

Indian Journal of Ophthalmology, 2013
Purpose : To assess the efficacy and advantages of femtosecond laser enabled keratoplasty (FLEK) over conventional penetrating keratoplasty (PKP) in advanced keratoconus.
Yathish Shivanna, Harsha Nagaraja, Thungappa Kugar, Rohit Shetty   +3 more
doaj   +1 more source

The long-term effects of genomic selection: 1. Response to selection, additive genetic variance, and genetic architecture

Genetics Selection Evolution, 2022
Background Genomic selection has revolutionized genetic improvement in animals and plants, but little is known about its long-term effects. Here, we investigated the long-term effects of genomic selection on response to selection, genetic variance, and ...
Yvonne C. J. Wientjes, Piter Bijma, Mario P. L. Calus, Bas J. Zwaan, Zulma G. Vitezica, Joost van den Heuvel   +5 more
doaj   +1 more source

Novel Genomic Loci Influencing Plasma Homocysteine Levels [PDF]

Stroke, 2006
Background and Purpose— Genetic factors that influence interindividual variation in levels of plasma homocysteine, a risk factor for vascular disease, are not fully understood. We performed linkage analyses to identify genomic regions that influence homocysteine levels in blacks and non-Hispanic ...
Iftikhar J, Kullo, Keyue, Ding, Eric, Boerwinkle, Stephen T, Turner, Thomas H, Mosley, Sharon L R, Kardia, Mariza, de Andrade   +6 more
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Acute corneal hydrops in keratoconus

Indian Journal of Ophthalmology, 2013
Acute corneal hydrops is a condition characterized by stromal edema due to leakage of aqueous through a tear in descemet membrane. The patient presents with sudden onset decrease in vision, photophobia, and pain.
Prafulla K Maharana, Namrata Sharma, Rasik B Vajpayee   +2 more
doaj   +1 more source

Cotton pan-genome retrieves the lost sequences and genes during domestication and selection

Genome Biology, 2021
Background Millennia of directional human selection has reshaped the genomic architecture of cultivated cotton relative to wild counterparts, but we have limited understanding of the selective retention and fractionation of genomic components. Results We
Jianying Li, Daojun Yuan, Pengcheng Wang, Qiongqiong Wang, Mengling Sun, Zhenping Liu, Huan Si, Zhongping Xu, Yizan Ma, Boyang Zhang, Liuling Pei, Lili Tu, Longfu Zhu, Ling-Ling Chen, Keith Lindsey, Xianlong Zhang, Shuangxia Jin, Maojun Wang   +17 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Long-term results of cornea collagen cross-linking with riboflavin for keratoconus

Indian Journal of Ophthalmology, 2013
Corneal collagen cross-linking with riboflavin and UVA light (CXL) is the only method designed to arrest the progression of keratoconus. Visual improvement generally starts 3 months after treatment.
Vinay Agrawal
doaj   +1 more source