Results 81 to 90 of about 1,321,379 (303)
Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
bioRxiv, 2019 Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear.Phil H. Lee, V. Anttila, H. Won, Y. Feng, Jacob Rosenthal, Zhaozhong Zhu, E. Tucker-Drob, M. Nivard, A. Grotzinger, D. Posthuma, M. Wang, Dongmei Yu, E. Stahl, R. Walters, R. Anney, L. Duncan, T. Ge, R. Adolfsson, T. Banaschewski, S. Belangero, E. Cook, G. Coppola, E. Derks, P. Hoekstra, J. Kaprio, A. Keski-Rahkonen, G. Kirov, H. Kranzler, J. Luykx, L. Rohde, C. Zai, E. Agerbo, M. Arranz, P. Asherson, Marie Bækvad-Hansen, G. Baldursson, M. Bellgrove, R. Belliveau, J. Buitelaar, C. Burton, J. Bybjerg-Grauholm, M. Casas, Felecia Cerrato, K. Chambert, C. Churchhouse, B. Cormand, J. Crosbie, S. Dalsgaard, D. Demontis, A. Doyle, Ashley L. Dumont, J. Elia, J. Grove, Olafur O. Gudmundsson, J. Haavik, H. Hakonarson, Christine S. Hansen, C. Hartman, Z. Hawi, A. Hervás, D. Hougaard, D. Howrigan, Hailiang Huang, J. Kuntsi, K. Langley, K. Lesch, P. Leung, S. Loo, Joanna Martin, Alicia R. Martin, J. McGough, S. Medland, J. Moran, O. Mors, P. Mortensen, R. Oades, D. Palmer, C. Pedersen, M. Pedersen, Triinu Peters, T. Poterba, J. Poulsen, J. Ramos-Quiroga, A. Reif, M. Ribasés, A. Rothenberger, P. Rovira, C. Sánchez-Mora, F. Satterstrom, R. Schachar, M. Artigas, S. Steinberg, H. Stefánsson, P. Turley, G. Walters, T. Werge, T. Zayats, D. Arking, F. Bettella, J. Buxbaum, J. Christensen, Ryan L. Collins, H. Coon, S. Rubeis, R. Delorme, D. Grice, T. Hansen, P. Holmans, S. Hope, C. Hultman, L. Klei, C. Ladd-Acosta, P. Magnússon, T. Nærland, M. Nyegaard, D. Pinto, P. Qvist, K. Rehnström, A. Reichenberg, J. Reichert, K. Roeder, G. Rouleau, E. Saemundsen, Stephan J Sanders, S. Sandin, B. S. Pourcain, K. Stefánsson, J. Sutcliffe, M. Talkowski, L. Weiss, A. Willsey, I. Agartz, Huda Akil, D. Albani, M. Alda, T. Als, A. Anjorin, L. Backlund, N. Bass, M. Bauer, B. Baune, F. Bellivier, Sarah E. Bergen, W. Berrettini, J. Biernacka, D. Blackwood, E. Bøen, M. Budde, W. Bunney, M. Burmeister, W. Byerley, E. Byrne, S. Cichon, Toni‐Kim Clarke, J. Coleman, N. Craddock, D. Curtis, P. Czerski, A. Dale, N. Dalkner, U. Dannlowski, F. Degenhardt, A. Florio, T. Elvsåshagen, B. Étain, S. Fischer, A. Forstner, L. Forty, J. Frank, M. Frye, J. Fullerton, K. Gade, Héléna A. Gaspar, E. Gershon, M. Gill, F. Goes, S. Gordon, K. Gordon-Smith, Melissa J. Green, T. Greenwood, M. Grigoroiu-Serbanescu, J. Guzmán-Parra, J. Hauser, M. Hautzinger, U. Heilbronner, S. Herms, P. Hoffmann, D. Holland, S. Jamain, Ian Jones, L. Jones, R. Kandaswamy, J. Kelsoe, James L. Kennedy, Oedegaard Ketil Joachim, S. Kittel-Schneider, M. Kogevinas, A. Koller, C. Lavebratt, C. Lewis, Qingqin S. Li, J. Lissowska, L. M. Loohuis, S. Lucae, A. Maaser, U. Malt, N. G. Martin, L. Martinsson, S. McElroy, F. McMahon, A. McQuillin, I. Melle, A. Metspalu, V. Millischer, P. Mitchell, G. Montgomery, G. Morken, D. Morris, B. Müller-Myhsok, N. Mullins, R. Myers, C. Nievergelt, M. Nordentoft, Annelie Nordin Adolfsson, M. Nöthen, R. Ophoff, M. Owen, S. Paciga, C. Pato, M. Pato, R. Perlis, A. Perry, J. Potash, C. Reinbold, M. Rietschel, M. Rivera, Mary Roberson, M. Schalling, P. Schofield, T. Schulze, L. Scott, A. Serretti, E. Sigurdsson, O. Smeland, E. Stordal, F. Streit, J. Strohmaier, T. Thorgeirsson, J. Treutlein, G. Turecki, A. Vaaler, E. Vieta, J. Vincent, Yunpeng Wang, S. Witt, P. Zandi, R. Adan, L. Alfredsson, T. Ando, H. Aschauer, J. Baker, V. Bencko, A. Bergen, A. Birgegård, V. B. Perica, H. Brandt, R. Burghardt, L. Carlberg, M. Cassina, M. Clementi, P. Courtet, Steven Crawford, S. Crow, J. Crowley, U. Danner, O. Davis, D. Degortes, J. DeSocio, D. Dick, C. Dina, E. Docampo, K. Egberts, S. Ehrlich, T. Espeseth, F. Fernández-Aranda, M. Fichter, L. Foretova, M. Forzan, G. Gambaro, I. Giegling, F. Gonidakis, P. Gorwood, Monica Gratacos Mayora, Yiran Guo, K. Halmi, K. Hatzikotoulas, J. Hebebrand, S. Helder, B. Herpertz-Dahlmann, W. Herzog, A. Hinney, H. Imgart, S. Jiménez-Murcia, Craig Johnson, J. Jordan, A. Julià, D. Kaminská, L. Karhunen, A. Karwautz, M. Kas, W. Kaye, M. Kennedy, Youl-Ri Kim, Lars Klareskog, K. Klump, G. Knudsen, M. Landén, S. Hellard, R. Levitan, Dong Li, P. Lichtenstein, M. Maj, S. Marsal, S. McDevitt, James Mitchell, P. Monteleone, A. Monteleone, Melissa A. Munn-Chernoff, B. Nacmias, M. Navratilova, J. O'toole, L. Padyukov, J. Pantel, H. Papežová, R. Rabionet, Anu Raevuori, N. Ramoz, T. Reichborn-Kjennerud, V. Ricca, Marion E. Roberts, D. Rujescu, F. Rybakowski, A. Scherag, U. Schmidt, J. Seitz, L. Slachtova, M. C. S. Landt, A. Słopień, S. Sorbi, L. Southam, M. Strober, A. Tortorella, F. Tozzi, J. Treasure, K. Tziouvas, A. Elburg, T. Wade, G. Wagner, E. Walton, Hunna J. Watson, H. Wichmann, D. Woodside, E. Zeggini, S. Zerwas, S. Zipfel, M. Adams, Till F. M. Andlauer, K. Berger, E. Binder, D. Boomsma, E. Castelao, L. Colodro-Conde, N. Direk, A. Docherty, E. Domenici, K. Domschke, E. Dunn, J. Foo, E. D. Geus, H. Grabe, S. Hamilton, Carsten Horn, J. Hottenga, David Mark Howard, M. Ising, S. Kloiber, D. Levinson, G. Lewis, P. Magnusson, H. Mbarek, C. Middeldorp, S. Mostafavi, D. Nyholt, B. Penninx, Roseann E. Peterson, G. Pistis, D. Porteous, M. Preisig, J. Quiroz, C. Schaefer, E. Schulte, Jianxin Shi, Danny J. Smith, P. Thomson, H. Tiemeier, R. Uher, S. Auwera, Myrna M. Weissman, Madeline Alexander, M. Begemann, E. Bramon, N. Buccola, M. Cairns, D. Campion, V. Carr, C. Cloninger, David Cohen, D. Collier, A. Corvin, L. DeLisi, G. Donohoe, F. Dudbridge, J. Duan, R. Freedman, P. Gejman, V. Golimbet, S. Godard, H. Ehrenreich, A. Hartmann, F. Henskens, M. Ikeda, N. Iwata, A. Jablensky, I. Joa, E. Jönsson, Brian J. Kelly, J. Knight, B. Konte, C. Laurent-Levinson, Jimmy Lee, T. Lencz, B. Lerer, C. Loughland, A. Malhotra, J. Mallet, C. Mcdonald, M. Mitjans, B. Mowry, K. Murphy, Robin M. Murray, F. O'Neill, Sang-Yun Oh, A. Palotie, C. Pantelis, A. Pulver, T. Petryshen, D. Quested, B. Riley, A. Sanders, U. Schall, S. Schwab, Rodney J. Scott, P. Sham, J. Silverman, K. Sim, Agnes A. Steixner, P. Tooney, J. Os, M. Vawter, D. Walsh, M. Weiser, D. Wildenauer, N. Williams, B. Wormley, Fuquan Zhang, C. Androutsos, P. Arnold, C. Barr, C. Barta, K. Bey, O. J. Bienvenu, D. Black, L. Brown, Cathy Budman, D. Cath, K. Cheon, V. Ciullo, Barbara Coffey, D. Cusi, L. Davis, D. Denys, C. Depienne, A. Dietrich, V. Eapen, P. Falkai, T. Fernandez, B. Garcia-Delgar, D. Geller, D. Gilbert, M. Grados +499 moresemanticscholar +1 more sourceHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceCollagen cross-linking in thin corneas
Indian Journal of Ophthalmology, 2013 Collagen cross-linking (CXL) has become the standard of care for progressive keratoconus, after numerous clinical studies have established its efficacy and safety in suitably selected eyes. The standard protocol is applicable in eyes which have a minimum Prema Padmanabhan, Abhishek Davedoaj +1 more sourceLongitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay +15 morewiley +1 more sourceThe genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation
Nature Communications, 2019 The epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ˜46 kb (R. Acton, Wei Yuan, Fei Gao, Yudong Xia, E. Bourne, E. Woźniak, J. Bell, K. Lillycrop, Jun Wang, E. Dennison, N. Harvey, C. Mein, T. Spector, P. Hysi, C. Cooper, C. Bell +15 moresemanticscholar +1 more sourceFusion transcript loci share many genomic features with non-fusion loci
BMC Genomics, 2015 Fusion transcripts are found in many tissues and have the potential to create novel functional products. Here, we investigate the genomic sequences around fusion junctions to better understand the transcriptional mechanisms mediating fusion transcription/splicing.John Lai, Jiyuan An, Inge Seim, Carina Walpole, Andrea Hoffman, Leire Moya, Srilakshmi Srinivasan, Joanna L. Perry-Keene, Chenwei Wang, Melanie L. Lehman, Colleen C. Nelson, Judith A. Clements, Jyotsna Batra +12 moreopenaire +4 more sourcesFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more source
