Results 101 to 110 of about 1,321,379 (303)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Acute corneal hydrops in keratoconus
Indian Journal of Ophthalmology, 2013 Acute corneal hydrops is a condition characterized by stromal edema due to leakage of aqueous through a tear in descemet membrane. The patient presents with sudden onset decrease in vision, photophobia, and pain.
Prafulla K Maharana +2 more
doaj +1 more source
Multiplexed Dynamic Imaging of Genomic Loci by Combined CRISPR Imaging and DNA Sequential FISH
Biophysical Journal, 2017 Visualization of chromosome dynamics allows the investigation of spatiotemporal chromatin organization and its role in gene regulation and other cellular processes.
Yodai Takei +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Generation of densely labeled oligonucleotides for the detection of small genomic elements
Cell Reports: MethodsSummary: The genome contains numerous regulatory elements that may undergo complex interactions and contribute to the establishment, maintenance, and change of cellular identity.
Clemens Steinek +7 more
doaj +1 more source
Long-term results of cornea collagen cross-linking with riboflavin for keratoconus
Indian Journal of Ophthalmology, 2013 Corneal collagen cross-linking with riboflavin and UVA light (CXL) is the only method designed to arrest the progression of keratoconus. Visual improvement generally starts 3 months after treatment.
Vinay Agrawal
doaj +1 more source
Live cell imaging of genomic loci using dCas9-SunTag system and a bright fluorescent protein
Protein & Cell, 2017 CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems have been harnessed for kinds of genome manipulation, including gene editing, transcription regulation, and chromosome loci imaging (Dominguez et al., 2016;
Huiying Ye, Zhili Rong, Ying Lin
semanticscholar +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Cross-linking for microbial keratitis
Indian Journal of Ophthalmology, 2013 The success of collagen cross-linking as a clinical modality to modify the clinical course in keratoconus seems to have fueled the search for alternative applications for this treatment.
Jayesh Vazirani, Pravin K Vaddavalli
doaj +1 more source
Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Antibiotic development is frequently plagued by the rapid emergence of drug resistance. However, assessing the risk of resistance development in the preclinical stage is difficult.
Á. Nyerges +17 more
semanticscholar +1 more source