Results 1 to 10 of about 301,899 (294)

Genome position specific priors for genomic prediction [PDF]

BMC Genomics, 2012
Background The accuracy of genomic prediction is highly dependent on the size of the reference population. For small populations, including information from other populations could improve this accuracy.
Brøndum Rasmus, Su Guosheng, Lund Mogens, Bowman Philip J, Goddard Michael E, Hayes Benjamin J   +5 more
doaj   +5 more sources

Ensemble AnalySis with Interpretable Genomic Prediction (EasiGP): Computational tool for interpreting ensembles of genomic prediction models [PDF]

The Plant Genome
An ensemble of multiple genomic prediction models has grown in popularity due to consistent prediction performance improvements in crop breeding. However, technical tools that analyze the predictive behavior at the genome level are lacking.
Shunichiro Tomura, Melanie J. Wilkinson, Owen Powell, Mark Cooper   +3 more
doaj   +2 more sources

Genomic prediction of coronary heart disease [PDF]

European Heart Journal, 2016
AbstractBackgroundGenetics plays an important role in coronary heart disease (CHD) but the clinical utility of a genomic risk score (GRS) relative to clinical risk scores, such as the Framingham Risk Score (FRS), is unclear.MethodsWe generated a GRS of 49,310 SNPs based on a CARDIoGRAMplusC4D Consortium meta-analysis of CHD, then independently tested ...
Gad Abraham, Aki S. Havulinna, Oneil G. Bhalala, Sean Byars, Alysha De Livera, Laxman Yetukuri, Emmi Tikkanen, Markus Perola, Heribert Schunkert, Eric J.G. Sijbrands, Aarno Palotie, Nilesh J. Samani, Veikko Salomaa, Samuli Ripatti, Michael Inouye   +14 more
openalex   +7 more sources

Predicting the accuracy of genomic predictions [PDF]

Genetics Selection Evolution, 2021
Abstract Background Mathematical models are needed for the design of breeding programs using genomic prediction. While deterministic models for selection on pedigree-based estimates of breeding values (PEBV) are available, these have not been fully developed for genomic selection, with a key missing component being the ...
Dekkers, Jack C. M., Su, Hailin, Cheng, Jian   +2 more
openaire   +4 more sources

Genomic Prediction for Twin Pregnancies [PDF]

Animals, 2021
Twinning is a multifactorial trait influenced by both genetic and environmental factors that can negatively impact animal welfare and economic sustainability on commercial dairy operations. To date, using genetic selection as a tool for reducing twinning rates on commercial dairies has been proposed, but not yet implemented.
Shaileen P. McGovern, Daniel J. Weigel, Brenda C. Fessenden, Dianelys Gonzalez-Peña, Natascha Vukasinovic, Anthony K. McNeel, Fernando A. Di Croce   +6 more
openaire   +3 more sources

Sibling variation in polygenic traits and DNA recombination mapping with UK Biobank and IVF family data

Scientific Reports, 2023
We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to investigate sibling variation in both phenotype and genotype. We compare phenotype (disease status, height, blood biomarkers) and genotype (polygenic scores, polygenic ...
Louis Lello, Maximus Hsu, Erik Widen, Timothy G. Raben   +3 more
doaj   +1 more source

Genomics-aided structure prediction [PDF]

Proceedings of the National Academy of Sciences, 2012
We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences.
Sulkowska, Joanna I., Morcos, Faruck, Weigt, Martin, Hwa, Terence, Onuchic, Jose N.   +4 more
openaire   +3 more sources

Genomic prediction using subsampling [PDF]

BMC Bioinformatics, 2017
Genome-wide assisted selection is a critical tool for the genetic improvement of plants and animals. Whole-genome regression models in Bayesian framework represent the main family of prediction methods. Fitting such models with a large number of observations involves a prohibitive computational burden. We propose the use of subsampling bootstrap Markov
Xavier, Alencar, Xu, Shizhong, Muir, William, Rainey, Katy Martin   +3 more
openaire   +2 more sources

Estimation of Pool Construction and Technical Error

Agriculture, 2021
Pooling animals with extreme phenotypes can improve the accuracy of genetic evaluation or provide genetic evaluation for novel traits at relatively low cost by exploiting large amounts of low-cost phenotypic data from animals in the commercial sector ...
John Keele, Tara McDaneld, Ty Lawrence, Jenny Jennings, Larry Kuehn   +4 more
doaj   +1 more source

Application of Genomic Data for Reliability Improvement of Pig Breeding Value Estimates

Animals, 2021
Replacement pigs’ genomic prediction for reproduction (total number and born alive piglets in the first parity), meat, fatness and growth traits (muscle depth, days to 100 kg and backfat thickness over 6–7 rib) was tested using single-step genomic best ...
Ekaterina Melnikova, Artem Kabanov, Sergey Nikitin, Maria Somova, Sergey Kharitonov, Petr Otradnov, Olga Kostyunina, Tatiana Karpushkina, Elena Martynova, Aleksander Sermyagin, Natalia Zinovieva   +10 more
doaj   +1 more source