Results 111 to 120 of about 536,771 (324)

Deep Kernel for Genomic and Near Infrared Predictions in Multi-environment Breeding Trials

G3: Genes, Genomes, Genetics, 2019
Kernel methods are flexible and easy to interpret and have been successfully used in genomic-enabled prediction of various plant species. Kernel methods used in genomic prediction comprise the linear genomic best linear unbiased predictor (GBLUP or GB ...
Jaime Cuevas, Osval Montesinos-López, Philomin Juliana, Carlos Guzmán, Paulino Pérez-Rodríguez, José González-Bucio, Juan Burgueño, Abelardo Montesinos-López, José Crossa   +8 more
doaj   +1 more source

Genomic prediction with machine learning in sugarcane, a complex highly polyploid clonally propagated crop with substantial non‐additive variation for key traits

, 2023
Chensong Chen, Owen Powell, Eric Dinglasan, Elizabeth M. Ross, Seema Yadav, Xianming Wei, Felicity Atkin, Emily Deomano, Ben J. Hayes   +8 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement

Genome Medicine
Background Accurate prediction of an individual’s predisposition to diseases is vital for preventive medicine and early intervention. Various statistical and machine learning models have been developed for disease prediction using clinico-genomic data ...
Yan Gao, Yan Cui
doaj   +1 more source

Prediction and analysis of functional RNA structures within the integrative genomics viewer [PDF]

, 2022
Warren B Rouse, Ryan J. Andrews, Nicholas J. Booher, Ji-Bo Wang, Michael E Woodman, Ernst R Dow, Theodore C Jessop, Walter N. Moss   +7 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Genomic selection on cacao for disease resistance : S04T08 [PDF]

, 2013
Under favorable conditions, diseases can cause losses up to 100% in cacao. Breeding has been the most effective strategy in reducing these losses. However, breeding is limited by the: a) long generation time; b) large tree size (9 m2/tree); c) multiple ...
Clément, Didier, Gramacho, Karina Peres, Lanaud, Claire, Lopes, Uilson Vanderlei, Monteiro, Wilson Reis, Phillips-Mora, Wilbert, Pires, José Luis   +6 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Identification of CpG islands using a bank of IIR lowpass filters [PDF]

, 2004
It has been known that biological sequences such as the DNA sequence display different kinds of patterns depending on their biological functions. This statistical difference can be exploited for identifying the region of interest, such as the protein ...
Vaidyanathan, P. P., Yoon, Byung-Jun
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source