Results 121 to 130 of about 301,899 (294)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Incorporating inter-relationships between different levels of genomic data into cancer clinical outcome prediction

, 2014
Dokyoon Kim, Hyunjung Shin, Kyung-Ah Sohn, Anurag Verma, Marylyn D. Ritchie, Ju Han Kim   +5 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Prediction of fruit texture with training population optimization for efficient genomic selection in apple [PDF]

, 2019
Morgane Roth, Mario Di Guardo, Walter Guerra, Hélène Muranty, Andrea Patocchi, Fabrizio Costa   +5 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Determining the Genetic Architecture and Breeding Potential of Quality Traits in Alfalfa (Medicago sativa L.) Through Genome-Wide Association Study and Genomic Prediction [PDF]

Ming Xu, Kai Zhu, Xueqian Jiang, Fan Zhang, Bilig Sod, Huijie Leng, Tian Zhang, Yanchao Xu, Tianhui Yang, Mingna Li, Xue Wang, Qingchuan Yang, Junmei Kang, Zhang Tie-jun, Lin Chen, Ruicai Long, Fei He   +16 more
openalex   +1 more source

Supplementary material: Improving genomic prediction of biomass using photosynthesis-related traits in Arabidopsis thaliana

, 2023
Muhammad Farooq
openalex   +2 more sources

Portability of genomic predictions trained on sparse factorial designs across two maize silage breeding cycles [PDF]

, 2023
Alizarine Lorenzi, Cyril Bauland, Sophie Pin, Delphine Madur, Valérie Combes, Carine Palaffre, Guillaume Colin, Gaëtan Touzy, Tristan Mary‐Huard, Alain Charcosset, Laurence Moreau   +10 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source