Results 11 to 20 of about 301,899 (294)

Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk Reduction

Frontiers in Endocrinology, 2019
For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce the risk of miscarriage and genetic disease in patients with advanced maternal age and risk of transmitting disease.
Nathan R. Treff, Nathan R. Treff, Jennifer Eccles, Jennifer Eccles, Lou Lello, Lou Lello, Elan Bechor, Jeffrey Hsu, Kathryn Plunkett, Kathryn Plunkett, Raymond Zimmerman, Raymond Zimmerman, Bhavini Rana, Bhavini Rana, Artem Samoilenko, Steven Hsu, Laurent C. A. M. Tellier, Laurent C. A. M. Tellier, Laurent C. A. M. Tellier   +18 more
doaj   +1 more source

Evaluation of the efficiency of genomic versus pedigree predictions for growth and wood quality traits in Scots pine

BMC Genomics, 2020
Background Genomic selection (GS) or genomic prediction is a promising approach for tree breeding to obtain higher genetic gains by shortening time of progeny testing in breeding programs.
Ainhoa Calleja-Rodriguez, Jin Pan, Tomas Funda, Zhiqiang Chen, John Baison, Fikret Isik, Sara Abrahamsson, Harry X. Wu   +7 more
doaj   +1 more source

Translating genomics into risk prediction [PDF]

Thorax, 2017
Cigarette smoking is a leading risk factor in the development of cardiovascular, pulmonary and malignant diseases worldwide.1 Yet, it remains one of the most challenging environmental exposures to quantify. Rudimentary categorisations of ‘never’, ‘former’ and ‘current’ smoker capture only a fraction of the complexity associated with the exposure ...
Emily S, Wan, Dawn L, DeMeo
openaire   +2 more sources

Genomic Prediction Using LD-Based Haplotypes in Combined Pig Populations

Frontiers in Genetics, 2022
The size of reference population is an important factor affecting genomic prediction. Thus, combining different populations in genomic prediction is an attractive way to improve prediction ability.
Haoqiang Ye, Zipeng Zhang, Duanyang Ren, Xiaodian Cai, Qianghui Zhu, Xiangdong Ding, Hao Zhang, Zhe Zhang, Jiaqi Li   +8 more
doaj   +1 more source

Predictive Genomics of Cardioembolic Stroke [PDF]

Stroke, 2009
Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver ...
Rachel Badovinac, Ramoni, Blanca E, Himes, Michele M, Sale, Karen L, Furie, Marco F, Ramoni   +4 more
openaire   +2 more sources

The impact of genomic relatedness between populations on the genomic estimated breeding values

Journal of Animal Science and Biotechnology, 2018
In genomic selection, prediction accuracy is highly driven by the size of animals in the reference population (RP). Combining related populations from different countries and regions or using a related population with large size of RP has been considered
Peipei Ma, Ju Huang, Weijia Gong, Xiujin Li, Hongding Gao, Qin Zhang, Xiangdong Ding, Chonglong Wang   +7 more
doaj   +1 more source

Bayesian methods for jointly estimating genomic breeding values of one continuous and one threshold trait. [PDF]

PLoS ONE, 2017
Genomic selection has become a useful tool for animal and plant breeding. Currently, genomic evaluation is usually carried out using a single-trait model.
Chonglong Wang, Xiujin Li, Rong Qian, Guosheng Su, Qin Zhang, Xiangdong Ding   +5 more
doaj   +1 more source

How Population Structure Impacts Genomic Selection Accuracy in Cross-Validation: Implications for Practical Breeding

Frontiers in Plant Science, 2020
Over the last two decades, the application of genomic selection has been extensively studied in various crop species, and it has become a common practice to report prediction accuracies using cross validation.
Christian R. Werner, R. Chris Gaynor, Gregor Gorjanc, John M. Hickey, Tobias Kox, Amine Abbadi, Gunhild Leckband, Rod J. Snowdon, Andreas Stahl, Andreas Stahl   +9 more
doaj   +1 more source

Increased Accuracy of Genomic Prediction Using Preselected SNPs from GWAS with Imputed Whole-Genome Sequence Data in Pigs

Animals, 2023
Enhancing the accuracy of genomic prediction is a key goal in genomic selection (GS) research. Integrating prior biological information into GS methods using appropriate models can improve prediction accuracy for complex traits.
Yiyi Liu, Yuling Zhang, Fuchen Zhou, Zekai Yao, Yuexin Zhan, Zhenfei Fan, Xianglun Meng, Zebin Zhang, Langqing Liu, Jie Yang, Zhenfang Wu, Gengyuan Cai, Enqin Zheng   +12 more
doaj   +1 more source

Pre-selecting markers based on fixation index scores improved the power of genomic evaluations in a combined Yorkshire pig population

Animal, 2020
Combining different swine populations in genomic prediction can be an important tool, leading to an increased accuracy of genomic prediction using single nucleotide polymorphism (SNP) chip data compared with within-population genomic.
S. Ye, H. Song, X. Ding, Z. Zhang, J. Li
doaj   +1 more source