Results 11 to 20 of about 551,388 (334)
Genomics-aided structure prediction [PDF]
Proceedings of the National Academy of Sciences, 2012 We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences.
Sulkowska, Joanna I. +4 more
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Estimation of Pool Construction and Technical Error
Agriculture, 2021 Pooling animals with extreme phenotypes can improve the accuracy of genetic evaluation or provide genetic evaluation for novel traits at relatively low cost by exploiting large amounts of low-cost phenotypic data from animals in the commercial sector ...
John Keele +4 more
doaj +1 more source
Application of Genomic Data for Reliability Improvement of Pig Breeding Value Estimates
Animals, 2021 Replacement pigs’ genomic prediction for reproduction (total number and born alive piglets in the first parity), meat, fatness and growth traits (muscle depth, days to 100 kg and backfat thickness over 6–7 rib) was tested using single-step genomic best ...
Ekaterina Melnikova +10 more
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Genomic prediction using subsampling [PDF]
BMC Bioinformatics, 2017 Genome-wide assisted selection is a critical tool for the genetic improvement of plants and animals. Whole-genome regression models in Bayesian framework represent the main family of prediction methods. Fitting such models with a large number of observations involves a prohibitive computational burden. We propose the use of subsampling bootstrap Markov
Alencar Xavier +3 more
openaire +3 more sources
Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk Reduction
Frontiers in Endocrinology, 2019 For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce the risk of miscarriage and genetic disease in patients with advanced maternal age and risk of transmitting disease.
Nathan R. Treff +18 more
doaj +1 more source
BMC Genomics, 2020 Background Genomic selection (GS) or genomic prediction is a promising approach for tree breeding to obtain higher genetic gains by shortening time of progeny testing in breeding programs.
Ainhoa Calleja-Rodriguez +7 more
doaj +1 more source
The Dimensionality of Genomic Information and Its Effect on Genomic Prediction [PDF]
Genetics, 2016 Abstract The genomic relationship matrix (GRM) can be inverted by the algorithm for proven and young (APY) based on recursion on a random subset of animals. While a regular inverse has a cubic cost, the cost of the APY inverse can be close to linear.
Pocrnic, Ivan +4 more
openaire +5 more sources
Genomic Prediction Using LD-Based Haplotypes in Combined Pig Populations
Frontiers in Genetics, 2022 The size of reference population is an important factor affecting genomic prediction. Thus, combining different populations in genomic prediction is an attractive way to improve prediction ability.
Haoqiang Ye +8 more
doaj +1 more source
Bayesian methods for jointly estimating genomic breeding values of one continuous and one threshold trait. [PDF]
PLoS ONE, 2017 Genomic selection has become a useful tool for animal and plant breeding. Currently, genomic evaluation is usually carried out using a single-trait model.
Chonglong Wang +5 more
doaj +1 more source
Interest of phenomic prediction as an alternative to genomic prediction in grapevine [PDF]
Plant Methods, 2021 Abstract Background Phenomic prediction has been defined as an alternative to genomic prediction by using spectra instead of molecular markers. A reflectance spectrum provides information on the biochemical composition within a tissue, itself being under genetic determinism. Thus, a relationship matrix built from spectra
Charlotte Brault +12 more
openaire +6 more sources