Results 41 to 50 of about 551,388 (334)
The Impact of Genomic Variation on Function (IGVF) Consortium [PDF]
arXiv, 2023 Our genomes influence nearly every aspect of human biology from molecular and cellular functions to phenotypes in health and disease. Human genetics studies have now associated hundreds of thousands of differences in our DNA sequence ("genomic variation") with disease risk and other phenotypes, many of which could reveal novel mechanisms of human ...
arxiv
Genomic Interpreter: A Hierarchical Genomic Deep Neural Network with 1D Shifted Window Transformer [PDF]
arXiv, 2023 Given the increasing volume and quality of genomics data, extracting new insights requires interpretable machine-learning models. This work presents Genomic Interpreter: a novel architecture for genomic assay prediction. This model outperforms the state-of-the-art models for genomic assay prediction tasks.
arxiv
Predictive Genomics of Cardioembolic Stroke [PDF]
Stroke, 2009 Cardioembolic stroke is a complex disease resulting from the interaction of numerous factors. Using data from Genes Affecting Stroke Risk and Outcome Study (GASROS), we show that a multivariate predictive model built using Bayesian networks is able to achieve a predictive accuracy of 86% on the fitted values as computed by the area under the receiver ...
Marco F. Ramoni +5 more
openaire +3 more sources
Genes, 2022 The extensive use of genomic selection (GS) in livestock and crops has led to a series of genomic-prediction (GP) algorithms despite the lack of a single algorithm that can suit all the species and traits. A systematic evaluation of available GP algorithms is thus necessary to identify the optimal GP algorithm for selective breeding in aquaculture ...
Kuiqin Wang, Ben Yang, Qi Li, Shikai Liu
openaire +2 more sources
Plants, 2020 Genomic selection accelerates genetic progress in crop breeding through the prediction of future phenotypes of selection candidates based on only their genomic information.
Mulusew Fikere +10 more
doaj +1 more source
Genomic prediction of coronary heart disease [PDF]
European Heart Journal, 2016 AbstractBackgroundGenetics plays an important role in coronary heart disease (CHD) but the clinical utility of a genomic risk score (GRS) relative to clinical risk scores, such as the Framingham Risk Score (FRS), is unclear.MethodsWe generated a GRS of 49,310 SNPs based on a CARDIoGRAMplusC4D Consortium meta-analysis of CHD, then independently tested ...
Heribert Schunkert +17 more
openaire +7 more sources
Frontiers in Plant Science, 2018 The development of high-throughput genotyping has made genome-wide association (GWAS) and genomic selection (GS) applications possible for both model and non-model species.
Giovanny Covarrubias-Pazaran +9 more
doaj +1 more source
Comparison of Single-Trait and Multi-Trait GBLUP Models for Genomic Prediction in Red Clover
AgronomyRed clover (Trifolium pratense) is a perennial forage legume wildly used in temperate regions, including northern Europe. Its breeders are under increasing pressure to obtain rapid genetic gains to meet the high demand for improved forage yield and ...
Johanna Osterman +6 more
doaj +1 more source
Genetics Selection Evolution, 2017 Background A better understanding of the genetic architecture of complex traits can contribute to improve genomic prediction. We hypothesized that genomic variants associated with mastitis and milk production traits in dairy cattle are enriched in ...
Lingzhao Fang +7 more
doaj +1 more source
The Plant Genome, 2018 Genomic prediction is becoming a popular plant breeding method to predict the genetic merit of lines. While some genomic prediction results have been reported in canola, none have been evaluated for blackleg disease.
Mulusew Fikere +11 more
doaj +1 more source