Results 51 to 60 of about 551,388 (334)

Genomic prediction based on runs of homozygosity [PDF]

Genetics Selection Evolution, 2014
Genomic prediction is based on the accurate estimation of the genomic relationships among and between training animals and selection candidates in order to obtain accurate estimates of the genomic estimated breeding values (GEBV). Various methods have been used to predict GEBV based on population-wide linkage disequilibrium relationships (G IBS ) or ...
Luan T., Yu X., Dolezal M., Bagnato A., Meuwissen T. H.   +4 more
openaire   +5 more sources

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Multi-environment analysis enhances genomic prediction accuracy of agronomic traits in sesame

Frontiers in Genetics, 2023
Introduction: Sesame is an ancient oilseed crop containing many valuable nutritional components. The demand for sesame seeds and their products has recently increased worldwide, making it necessary to enhance the development of high-yielding cultivars ...
Idan Sabag, Idan Sabag, Ye Bi, Zvi Peleg, Gota Morota   +4 more
doaj   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements [PDF]

, 2013
Background: Recent assays for individual-specific genome-wide DNA methylation profiles have enabled epigenome-wide association studies to identify specific CpG sites associated with a phenotype. Computational prediction of CpG site-specific methylation levels is important, but current approaches tackle average methylation within a genomic locus and are
arxiv   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Deep Biological Pathway Informed Pathology-Genomic Multimodal Survival Prediction [PDF]

arXiv, 2023
The integration of multi-modal data, such as pathological images and genomic data, is essential for understanding cancer heterogeneity and complexity for personalized treatments, as well as for enhancing survival predictions. Despite the progress made in integrating pathology and genomic data, most existing methods cannot mine the complex inter ...
arxiv  

Genomic prediction with haplotype blocks in wheat

Frontiers in Plant Science, 2023
Haplotype blocks might carry additional information compared to single SNPs and have therefore been suggested for use as independent variables in genomic prediction. Studies in different species resulted in more accurate predictions than with single SNPs in some traits but not in others. In addition, it remains unclear how the blocks should be built to
Yohannes Fekadu Difabachew, Matthias Frisch, Anna Luise Langstroff, Andreas Stahl, Benjamin Wittkop, Rod J. Snowdon, Michael Koch, Martin Kirchhoff, László Cselényi, Markus Wolf, Markus Wolf, Jutta Förster, Sven Weber, Uche Joshua Okoye, Carola Zenke-Philippi   +14 more
openaire   +3 more sources

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Using machine learning to improve the accuracy of genomic prediction of reproduction traits in pigs

Journal of Animal Science and Biotechnology, 2022
Background Recently, machine learning (ML) has become attractive in genomic prediction, but its superiority in genomic prediction over conventional (ss) GBLUP methods and the choice of optimal ML methods need to be investigated.
Xue Wang, Shaolei Shi, Guijiang Wang, Wenxue Luo, Xia Wei, Ao Qiu, Fei Luo, Xiangdong Ding   +7 more
doaj   +1 more source