Results 61 to 70 of about 546,866 (293)

Genomic selection in livestock populations

Genetics Research, 2010
SummaryMost traits of economic importance in livestock are either quantitative or complex. Despite considerable efforts, there has been only limited success in identifying the polymorphisms that cause variation in these traits. Nevertheless, selection based on estimated breeding values (BVs), calculated from data on phenotypic performance and pedigree ...
Goddard, Michael E., Hayes, Ben J., Meuwissen, Theo H. E.   +2 more
openaire   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Genome-wide association and genomic prediction of thermal tolerance in olive flounders (Paralichthys olivaceus): A validation study

Aquaculture Reports
Global warming poses a significant challenge to aquaculture, with increasing water temperatures adversely affecting the growth, reproduction, and survival of aquatic species.
H.M.V. Udayantha, Jeongeun Kim, Gaeun Kim, Jihun Lee, Sukkyoung Lee, Cheong-Uk Park, David B. Jones, Cecile Massault, Dean R. Jerry, D.S. Liyanage, Jehee Lee   +10 more
doaj   +1 more source

Quality Evaluation, Phytochemical Characteristics and Estimation of Beta-Carotene Hydroxylase 2 (Chy2) Alleles of Interspecific Potato Hybrids

Agronomy, 2021
Potatoes contain antioxidants such as flavonoids, carotenoids and ascorbic acid. High level consumption worldwide makes potato a valuable source of phytonutrients. Developing new potato varieties with high nutritional value in combination with resistance
Oksana B. Polivanova, Ekaterina M. Gins, Evgeny A. Moskalev, Maria S. Voinova, Alina K. Koroleva, Anatoly Zh. Semenov, Anastasia B. Sivolapova, Anna S. Ivanova, Oleg G. Kazakov, Evgeny A. Simakov, Nadezhda A. Chalaya, Elena V. Rogozina, Svetlana V. Goryunova   +12 more
doaj   +1 more source

Performance of Genomic Selection in Mice [PDF]

Genetics, 2008
Abstract Selection plans in plant and animal breeding are driven by genetic evaluation. Recent developments suggest using massive genetic marker information, known as “genomic selection.” There is little evidence of its performance, though.
Legarra, Andres, Robert-Granié, Christèle, Manfredi, Eduardo, Elsen, J.M.   +3 more
openaire   +6 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Comparative Transcriptome Analysis of White and Orange Skin of Clownfish Identifying Differentially Expressed Genes (DEGs) Underlying Pigment Expression

Fishes
Although the clownfish, Amphiprion ocellaris (A. ocellaris), is a popular ornamental marine fish worldwide, the mechanisms underlying color pattern variation remain unclear. Given that the Platinum-type clownfish, nearly entirely white, has high economic
Heegun Lee, Taehyug Jeong, Yeongkuk Kim, Sumi Jung, Jiyong Choi, Min-min Jung, Seunghwan Ko, Hayeong Oh, Juhyeok Kim, Jehee Lee, Seung Hwan Lee   +10 more
doaj   +1 more source

New cycle, same old mistakes? Overlapping vs. discrete generations in long-term recurrent selection

BMC Genomics, 2022
Background Recurrent selection is a foundational breeding method for quantitative trait improvement. It typically features rapid breeding cycles that can lead to high rates of genetic gain.
Marlee R. Labroo, Jessica E. Rutkoski
doaj   +1 more source