Results 41 to 50 of about 244,292 (287)

Optimal capacity sharing for global genomic surveillance

Epidemics, 2023
Recent technological advances and substantial cost reductions have made the genomic surveillance of pathogens during pandemics feasible. Our paper focuses on full genome sequencing as a tool that can serve two goals: the estimation of variant prevalences, and the identification of new variants.
Zsombor Z. Méder, Robert Somogyi
openaire   +4 more sources

Two Years of Genomic Surveillance in Belgium during the SARS-CoV-2 Pandemic to Attain Country-Wide Coverage and Monitor the Introduction and Spread of Emerging Variants

Viruses, 2022
An adequate SARS-CoV-2 genomic surveillance strategy has proven to be essential for countries to obtain a thorough understanding of the variants and lineages being imported and successfully established within their borders.
Lize Cuypers, Simon Dellicour, Samuel L. Hong, Barney I. Potter, Bruno Verhasselt, Nick Vereecke, Laurens Lambrechts, Keith Durkin, Vincent Bours, Sofieke Klamer, Guillaume Bayon-Vicente, Carl Vael, Kevin K. Ariën, Ricardo De Mendonca, Oriane Soetens, Charlotte Michel, Bertrand Bearzatto, Reinout Naesens, Jeremie Gras, Anne Vankeerberghen, Veerle Matheeussen, Geert Martens, Dagmar Obbels, Ann Lemmens, Bea Van den Poel, Ellen Van Even, Klara De Rauw, Luc Waumans, Marijke Reynders, Jonathan Degosserie, Piet Maes, Emmanuel André, Guy Baele   +32 more
doaj   +1 more source

Prediction and prevention of the next pandemic zoonosis. [PDF]

, 2012
Most pandemics--eg, HIV/AIDS, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes.
Carroll, Dennis, Daszak, Peter, Karesh, William B, Lipkin, W Ian, Mazet, Jonna AK, Morse, Stephen S, Parrish, Colin R, Woolhouse, Mark, Zambrana-Torrelio, Carlos   +8 more
core   +1 more source

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]

, 2018
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés, Pérez de Camino Cantos, Dolores, Silva, Sonia   +2 more
core   +1 more source

Whole-genome sequencing for national surveillance of Shiga toxin–producing Escherichia coli O157 [PDF]

, 2015
Background. National surveillance of gastrointestinal pathogens, such as Shiga toxin–producing Escherichia coli O157 (STEC O157), is key to rapidly identifying linked cases in the distributed food network to facilitate public health interventions.
Adak, Goutam, Ashton, Philip M., Byrne, Lisa, Cowley, Lauren A, Dallman, Timothy J, Ellis, Richard J, Elson, Richard, Grant, Kathie, Green, Jonathan, Hanage, William P, Jenkins, Claire, Perry, Neil T, Petrovska, Liljana, Underwood, Anthony, Wain, John   +14 more
core   +1 more source

Understanding the global rise of artemisinin resistance: Insights from over 100,000 Plasmodium falciparum samples

eLife
Artemisinin partial resistance (ART-R) in Plasmodium falciparum is a major challenge to malaria control globally. Over the last two decades, ART-R has spread widely across Southeast Asia, undermining public health strategies and hindering elimination. As
Andrew J Balmer, Nina FD White, Eyyüb S Ünlü, Chiyun Lee, Richard D Pearson, Jacob Almagro-Garcia, Cristina Ariani   +6 more
doaj   +1 more source

Detailed evaluation of data analysis tools for subtyping of bacterial isolates based on whole genome sequencing : Neisseria meningitidis as a proof of concept [PDF]

, 2019
Whole genome sequencing is increasingly recognized as the most informative approach for characterization of bacterial isolates. Success of the routine use of this technology in public health laboratories depends on the availability of well-characterized ...
Bertrand, Sophie, De Keersmaecker, Sigrid CJ, Marchal, Kathleen, Mattheus, Wesley, Roosens, Nancy HC, Saltykova, Assia   +5 more
core   +1 more source

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. [PDF]

, 2019
The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research,
Bristow, Claire C, Cristillo, Anthony D, Dillon, Jo-Anne, Dong, Huan, Grad, Yonatan H, Kirkcaldy, Robert D, Klausner, Jeffrey D, Lawrence, Kenneth, Morris, Sheldon R, Nicholas, Robert A, Oldach, David, Rice, Peter A, Shafer, William Maurice, Torrone, Elizabeth, Wi, Teodora E, Zhou, Pei   +15 more
core   +1 more source

Quantifying Pathogen Surveillance Using Temporal Genomic Data [PDF]

mBio, 2013
ABSTRACT With the advent of deep sequencing, genomic surveillance has become a popular method for detection of infectious disease, supplementing information gathered by classic clinical or serological techniques to identify host-determinant markers and trace the origin of transmission. However, two main factors complicate genomic
Chan, Joseph Minhow, Rabadan, Raul
openaire   +4 more sources

RDT performance through high-throughput bead-based antigen detection during malaria school survey in Senegal

Frontiers in Parasitology
BackgroundRapid Diagnostic Tests (RDTs) remain the frontline tool for malaria diagnosis, but their performance in detecting low-density infections is variable and poorly characterized at the population level.ObjectiveThis study aimed to evaluate the ...
Mamadou Alpha Diallo, Ibrahima M. Ndiaye, Djiby Sow, Mame Cheikh Seck, Khadim Diongue, Mariama Touré, Katerine E. Battle, Bassirou Ngom, Mouhamad Sy, Amy Gaye, Yaye Dié Ndiaye, Mamane Nassirou Garba, Aida Sadikh Badiane, Aita Sene, Medoune Ndiop, Jules François Gomis, Sarah K. Volkman, Doudou Sene, Bronwyn L. MacInnis, Ibrahima Diallo, Mouhamadou Ndiaye, Dyann F. Wirth, Daouda Ndiaye   +22 more
doaj   +1 more source