Results 111 to 120 of about 5,806,293 (254)

Comparative genotoxic potential of 27 polycyclic aromatic hydrocarbons in three human cell lines

, 2020
International audiencePolycyclic Aromatic Hydrocarbons (PAHs) form a family of compounds that are generally found in complex mixtures. PAHs can lead to the development of carcinogenesis.
Audebert, Marc, Tebby, C., Cravedi, Jean Pierre,, Graillot, Vanessa, Tomasetig, Florence, Pery, Alexandre R.R., Cravedi, Jean Pierre, J. P., Zeman, F.   +7 more
core   +1 more source

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal
The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
doaj   +1 more source

Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion

Cell Reports
Summary: Environmental exposures significantly influence cancer risk, but their mutational impact remains unclear. We perform whole-exome sequencing of hepatocellular carcinomas (HCCs) from B6C3F1/N mice that arise spontaneously with age (2 years old) or
Miaofei Xu, Jianying Li, Yun-Chung Hsiao, Ramesh C. Kovi, Jian-Liang Li, Leszek J. Klimczak, Laura Riva, David Adams, Pierre R. Bushel, B. Alex Merrick, Dmitry Gordenin, John R. Bucher, Robert C. Sills, Arun R. Pandiri   +13 more
doaj   +1 more source

Risk assessment of herbal supplements containing ingredients that are genotoxic and carcinogenic

, 2019
Botanicals and botanical preparations including plant food supplements as well as medicinal herbal supplements can contain possible beneficial health compounds, but also ingredients of concern. Compounds that are both genotoxic and carcinogenic have been
Prinsloo, Gerhard, Vervoort, Jacques, Rietjens, I.M.C.M., Steffens, Francois   +3 more
core   +1 more source

Levels of Genotoxic and Carcinogenic Compounds in Plant food Supplements and Associated Risk Assessment

, 2011
The present study describes the selection, analysis and risk assessment of genotoxic and carcinogenic compounds of botanicals and botanical preparations which can be found in plant food supplements (PFS).
Patrizia Restani, S. J. P. L. van den Berg, Luc Delmulle, Suzanne J. P. L. van den Berg, Delmulle, L., Berg, S.J.P.L., van den, P. Restani, Restani, P., Marelle G. Boersma, M. G. Boersma, I. M. C. M. Rietjens, Boersma, M.G., L. Delmulle, Ivonne M. C. M. Rietjens, Rietjens, I.   +14 more
core   +1 more source

Oral and Fecal Microbial Dysbiosis as Non‐Invasive Diagnostic Biomarkers for Gastrointestinal Cancers: A Systematic Review and Meta‐Analysis of Diagnostic Accuracy

International Journal of Cancer, EarlyView.
ABSTRACT Gastrointestinal (GI) cancers, including esophageal (EC), gastric (GC), and colorectal cancer (CRC), impose a substantial global burden, with early detection remaining crucial for improving patient outcomes. The oral and gut microbiota are increasingly implicated in cancer development and hold promise as sources of non‐invasive biomarkers ...
Saidi Hu, Zhouyan Chen, Yanxia Li, Qingyan Liao, Mingdong Luo, Danyang Song, Hanyue Yu, Yuetong Gao, Shuanglong Yang, Siran Wan, Shunhong Zhang, Chenchen Luo, Lin‐Yong Zhao   +12 more
wiley   +1 more source

Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells.

Cell Stem Cell, 2022
Ferrari S, Jacob A, Cesana D, Laugel M, Beretta S, Varesi A, Unali G, Conti A, Canarutto D, Albano L, Calabria A, Vavassori V, Cipriani C, Castiello MC, Esposito S, Brombin C, Cugnata F, Adjali O, Ayuso E, Merelli I, Villa A, Di Micco R, Kajaste-Rudnitski A, Montini E, Penaud-Budloo M, Naldini L.   +25 more
europepmc   +1 more source

Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic.

, 2010
This paper presents the work of an expert group established by the International Life Sciences Institute - European branch (ILSI Europe) to follow up the recommendations of an international conference on "Risk Assessment of Compounds that are both ...
Leblanc, J.C., Schlatter, J., Williams, G., Benford, D., Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Renwick, A.G., Slob, W., DiNovi, M., Setzer, W., Coulet, M., Bolger, P.M., Smith, B., Wildemann, T., Carthew, P., Peter Cadby, Michael DiNovi, R. Woodrow Setzer, Benjamin Smith   +18 more
core   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source