Results 121 to 130 of about 36,448 (257)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde   +4 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde   +4 more
wiley   +1 more source

Dose‐dependent efficacy of a novel dsRNA‐based solution containing vadescana for Varroa destructor control

open access: yesPest Management Science, EarlyView.
Vadescana is a novel dsRNA‐based product that targets Varroa fecundity. Vadescana applied at 4 g/brood box in one application was most effective at reducing Varroa populations for up to 18 weeks. Abstract BACKGROUND A novel dsRNA‐based product, containing a molecule called vadescana, interferes with Varroa destructor (Anderson and Trueman) fecundity ...
Briana E Price   +5 more
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao   +3 more
wiley   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

open access: yesResponsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun   +8 more
wiley   +1 more source

A Platform for the Actuation of Magnetically Labeled Skeletal Muscle Cells Using Dynamic Magnetic Stimulation

open access: yesSmall, EarlyView.
A magnetic stimulation platform for the remote stimulation of cells is presented, consisting of a magnetic stimulator and magnetic microspheres. Skeletal muscle cells are labeled with magnetic microspheres, which act as local magnetic actuators on the cells upon application of the magnetic field.
Tayná C. Rodrigues   +14 more
wiley   +1 more source

Long-Term PET-Nanoplastic Exposure Alters DNA Damage Response Capacity in BEAS-2B Human Bronchial Epithelial Cells. [PDF]

open access: yesInt J Mol Sci
Morataya-Reyes M   +7 more
europepmc   +1 more source

MXene Bioinks for 3D Bioprinting: Design and Translation

open access: yesSmall, EarlyView.
This study establishes a comprehensive framework for MXene‐based bioinks in 3D bioprinting, highlighting the interplay between rheological engineering and electroactive hydrogels. By optimizing electrical percolation and mediated signaling, these formulations drive tissue‐specific biological outcomes and accelerated regeneration.
Begüm Sarac   +2 more
wiley   +1 more source

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