Results 141 to 150 of about 5,806,293 (254)

High‐Content Screening Comparison of 1R6F Cigarette Smoke Extract and Selected Heated Tobacco and Electronic Vapour Product Aerosol Extracts in Endothelial and Bronchial Epithelial Cell Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Cigarettes induce oxidative stress and DNA damage, processes that contribute to cardiovascular and pulmonary disease. High content screening (HCS) is an increasingly valuable tool for comparative toxicology because it enables simultaneous quantification of multiple mechanistic endpoints at single‐cell resolution. In this study, HCS was used to
Edgar Trelles Sticken, Konstantinos Papikinos, Fiona Chapman, Roman Wieczorek, Sarah Jean Pour, Torge Evenburg, Sandra Otte, Tiandan Wu, Liam Simms, Matthew Stevenson   +9 more
wiley   +1 more source

Cytotoxic and Genotoxic Effects in Buccal Cells of Sandstone Quarry Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mineral extraction poses significant occupational health risks, particularly from respirable crystalline silica exposure. Sandstone quarrying generates substantial dust, yet evidence of its genotoxic effects remains limited. This study investigated cytogenotoxic damage in sandstone quarry workers from southern Brazil using the buccal ...
Ana Carolina de Quadros Duarte, Maria Isabela Toniazzo, Rayne Vallada da Luz, Cleisson Guimarães Bueno, Daniela Müller de Quevedo, Luciano Basso da Silva, Daiane Bolzan Berlese   +6 more
wiley   +1 more source

Epigenotoxicity:Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk ...
Faulk, Christopher, LaRocca, Jessica, Marchetti, Francesco, Godschalk, Roger, van Benthem, Jan   +4 more
core   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Metal Accumulation, Liver Histopathology, and Human Health Risk Assessment Across Different Trophic Guilds in a Mining‐Affected Neotropical River

Journal of Applied Toxicology, EarlyView.
ABSTRACT Metal pollution in aquatic environments represents a recurring global concern; however, traditional paradigms often assume linear bioaccumulation patterns that may fail under catastrophic contamination scenarios. This study evaluated metal concentrations in water, sediment, and tissues of 10 fish species from different trophic guilds in the ...
Breno Thuller, Alessandro Loureiro Paschoalini, Fabio Pereira Arantes, Cristiano Schetini de Azevedo, Elizete Rizzo, Nilo Bazzoli   +5 more
wiley   +1 more source

Ionic liquids: structure–toxicity relationships, predictive toxicology, and sustainable design

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Ionic liquids (ILs) have often been described as green alternatives to conventional solvents because of their negligible vapor pressure and highly tunable properties. However, low volatility does not necessarily translate into environmental safety, as their biological and ecological effects are strongly influenced by molecular structure.
Letícia Zanchet, Letícia Guerreiro da Trindade, Monize Bürck, Gabriela Rosa dos Santos, Matheus Klein, Aryel Heitor Ferreira   +5 more
wiley   +1 more source

Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2. [PDF]

Food Chem X
Zhu H, Zhou K, Li Y, Zhou Q, Peng M, Wu X, Mao X, Yang Q.   +7 more
europepmc   +1 more source

An Increased Genotoxic Risk in Lymphocytes from Phototherapy-Treated Hyperbilirubinemic Neonates. [PDF]

Iran Biomed J, 2017
Mesbah-Namin SA, Shahidi M, Nakhshab M.
europepmc   +1 more source

Evolution of Pigments in Artificially Aged Polyethylene Plastics: A Raman Study

Journal of Raman Spectroscopy, EarlyView.
The evolution of specific pigments included in plastics exposed to UVA is studied using Raman spectroscopy. This approach is applicable to both organic and inorganic pigments and is facilitated by resonance mechanisms. ABSTRACT The degradation mechanisms of polymers under UV exposure and the evolution of additives are a major concern due to their ...
Lucie Dewyspelaere, Lénaïk Belec, Isabelle Martin, Véronique Madigou, Olivia Gérigny, Alexandre Merlen   +5 more
wiley   +1 more source

Aflatoxin contamination in dried fruits and nuts in Bangladesh: Occurrence, dietary exposure, and health risk assessment

JSFA reports, EarlyView.
Abstract Background Dried fruits and nuts are widely consumed for their desirable sensory qualities and high nutritional value, providing essential nutrients such as proteins, healthy fatty acids, potassium, dietary fiber, and bioactive compounds. However, they are highly susceptible to aflatoxin contamination, particularly in humid tropical regions ...
Tasniya Akter, Mohammad Tariqul Hassan, Abira Nowar, Farhana Rinky, Sharmin Rumi Alim   +4 more
wiley   +1 more source