Results 161 to 170 of about 5,806,293 (254)

The Oncologic Ambivalence of Longevity Interventions in Photoaged Skin

JEADV Clinical Practice, EarlyView.
This graphical abstract presents a stage‐dependent framework for longevity interventions in photoaged skin. UV exposure drives progression from photodamage to field cancerization and skin cancer. Systemic interventions may modulate stress‐response pathways throughout the body, whereas energy‐based procedures generate spatially confined responses ...
Erik Senger, Lea Kurzen, Hjalmar Kurzen
wiley   +1 more source

Olaparib Blocks Oxidative Stress‐Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK‐Driven Autophagic Flux

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric acute lung injury (ALI) is a life‐threatening syndrome defined by dysregulated pulmonary inflammation and impaired alveolar gas exchange, with limited therapeutic interventions. This study aims to evaluate the therapeutic efficacy and mechanistic basis of Olaparib, a clinically approved PARP inhibitor, using in vitro and in vivo ...
Fen Gong, Mei‐Ling Yu, Zheng‐Rong Chen, Mei Li, Xu Sang, Yong‐Dong Yan   +5 more
wiley   +1 more source

Environmentally relevant concentrations of thiamethoxam cause cytotoxic and genotoxic damage in bullfrog (Lithobates catesbeianus) tadpoles. [PDF]

Ecotoxicology
De Oliveira AA, Barradas MC, Tomaz AA, da Silva Lima D, Assis JVB, Chaves AR, Vieira TB, Monteiro MS, Sarmento RA, de Souza Saraiva A, De Melo E Silva D.   +10 more
europepmc   +1 more source

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

From Symbiont to Potential Carcinogenic Contributor: Examining the Pathogenic Evolution of <i>Morganella morganii</i> in Colorectal Cancer. [PDF]

Infect Drug Resist
Soleymanpour K, Shokouhi B, Kafil HS.
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Antibiotic-Induced Genotoxicity: Molecular Mechanisms, Cytogenetic Damage, and Implications for Human Health. [PDF]

Int J Mol Sci
Berber AA, Yıldız E, Demir ŞN, Kenanoğlu NA, Berber N.   +4 more
europepmc   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Advancing genotoxicity assessment with transcriptomic biomarkers: from 2D to 3D HepaRG spheroid models. [PDF]

Toxicol Sci
Saleh M, Hogeveen K, Thienpont A, Demuynck E, Fessard V, Mertens B, Le Hégarat L.   +6 more
europepmc   +1 more source

Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum, Catherine Lee, Tippi MacKenzie, Billie Lianoglou, Agnieszka Czechowicz   +4 more
wiley   +1 more source