Results 91 to 100 of about 5,806,293 (254)

Exposure of population to genotoxic factors from the environment

, 2006
Genotoxic factor is any factor that can show alternation of the DNA structure. Genotoxic factors are common and prevalent factors in our modern life, and carry an important and significant risk in our society.
Bleich, Oz
core  

Circular Transitions in Healthcare Waste Management in Vietnam: An Institutional Perspective

Business Strategy and the Environment, EarlyView.
ABSTRACTHealthcare waste management (HCWM) is a growing environmental and public health concern. This study explores how the institutional pressures that shape HCWM practices evolve toward circularity through coercive, normative, and mimetic isomorphisms and how these mechanisms influence organisational behaviour in Vietnam, a complex, highly regulated
V. Tuomala, S. Schiffling, R. McClelland, S. K. Kok, D. T. Tran, P. Hoang, A. Nguyen, A. Ngo   +7 more
wiley   +1 more source

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

Assessment of the genotoxic impact of pesticides on farming communities in the countryside of Santa Catarina State, Brazil

Genetics and Molecular Biology, 2011
The aim of this study was to assess the use of pesticides on farms located in the Lambedor River watershed in Guatambu, State of Santa Catarina, as well as to determine, by micronucleus testing, the risk of genotoxic impact.
Jaqueli Salvagni, Raquel Zeni Ternus, Alexandre Meneghello Fuentefria   +2 more
doaj  

Genotoxicity of Coffee, Coffee By-Products, and Coffee Bioactive Compounds: Contradictory Evidence from In Vitro Studies

Toxics
Coffee and coffee by-products, such as coffee cherries, coffee flowers, coffee leaves, green beans, roasted coffee, instant coffee, spent coffee grounds, and silverskin, contain a complex mixture of bioactive compounds that may exhibit both genotoxic and
Maryam Monazzah, Dirk W. Lachenmeier
doaj   +1 more source

Impacts of Low-Dose Gamma-Radiation on Genotoxic Risk in Aquatic Ecosystems

Dose-Response, 2007
Chinook salmon cells were exposed to gamma radiation and chromosome damage was assessed using the micronucleus assay. The salmon cells were resistant to radiation at all doses compared to human and mammalian cells.
Cheryl L. Cassidy, Jennifer A. Lemon, Douglas R. Boreham   +2 more
doaj   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil, Sathej Gopalakrishnan, Jennifer Dong, Karthik Venkatakrishnan, Charlotte Kloft, Wilhelm Huisinga, Lena Klopp‐Schulze   +6 more
wiley   +1 more source

Urothelial genotoxicity of household chemicals in healthy canine urinary bladder organoids relative to observed urinary exposures in pet dogs

Frontiers in Veterinary Science
IntroductionUrothelial carcinoma (UC) in pet dogs closely resembles human muscle-invasive UC, which is associated with environmental chemical carcinogens.
Hannah M. Peterson, Christopher Zdyrski, Christopher Zdyrski, Karin Allenspach, Karin Allenspach, Jonathan P. Mochel, Jonathan P. Mochel, Jonathan P. Mochel, Lauren A. Trepanier   +8 more
doaj   +1 more source

A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress

BMC Cancer, 2017
Background Mantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation.
Khaoula Ben Younes, Simon Body, Élodie Costé, Pierre-Julien Viailly, Hadjer Miloudi, Clémence Coudre, Fabrice Jardin, Fatma Ben Aissa-Fennira, Brigitte Sola   +8 more
doaj   +1 more source

Xylose Acetals ‐ a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova, Cicely M. Warne, Hugo Pétremand, Laura König‐Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M. Guebitz, Jeremy Luterbacher, Alessandro Pellis   +8 more
wiley   +1 more source