Results 71 to 80 of about 5,806,293 (254)

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Mutagenic and genotoxic activity of particulate matter MP2,5, in Pamplona, North Santander, Colombia

Iatreia, 2012
Objective: To study the mutagenic and genotoxic activities of particulate material (MP2,5 collected in Pamplona, Norte de Santander, Colombia.Materials and methods: MP2,5 was monitored by means of a Partisol 2025 sequential air sampler with Plus Palmflex
Martínez Montañez, Mónica Liseth, Meléndez Gélvez, Iván, Quijano Parra, Alfonso   +2 more
doaj  

Natural and Artificial Sweeteners a Blessing or Curse: A Phyto-genotoxic Study in Allium cepa L. Root Tip Cells

Journal of Applied Research in Plant Sciences
The study investigated the comparative phyto-genotoxic impacts of natural and artificial sweetener brands using the Allium cepa L. (onion) assay to predict potential phyto-genotoxic associated with long-term intake.
Sadaf Tabasum Qureshi, Sindhu Zahid, Muhammad Ramzan Laghari, Shafique Ahmed Rajper, Shamshad Ali Jarwar, Sooraj Kumar Bheel, Kainat Anwar Arian   +6 more
doaj   +1 more source

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Gauthier, Laury, Polard, Thierry, Jean, Séverine, G. Merlina, Pinelli, Eric, S. Jean, Merlina, Georges, T. Polard, E. Pinelli, C. Laplanche, L. Gauthier, Laplanche, Christophe   +11 more
core   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Evaluation of genotoxic and oxidative effects in workers exposed to jet propulsion fuel

, 2011
Jet fuel is a common occupational exposure risk among military and civilian populations. The purpose of this study was to evaluate genotoxic and oxidative effects in workers occupational exposure to jet propulsion fuel (JP-8)
Erdem, Onur, Onur Erdem, Ahmet Sayal, Ahmet Aydın, Ayşe Eken, EKEN, Ayşe, Aydin, Ahmet, Akay, Cemal, Sayal, Ahmet, Cemal Akay   +9 more
core   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

A review on genotoxic and mutagenic effects of monoterpenes

, 2017
This review sketches genotoxic and mutagenic potentials of monoterpenes, which find outs some important genotoxic, mutagenic as well as non-genotoxic and non-mutagenic monoterpenes. Monoterpenes are the important natural products.
Muhammad Islam
core   +1 more source