Results 51 to 60 of about 5,806,293 (254)
Molecular Therapy: Methods & Clinical Development, 2021 Hematopoietic stem and progenitor cell (HSPC) lentiviral gene therapy is a promising strategy toward a lifelong cure for hemophilia A (HA). The primary risks associated with this approach center on the requirement for pre-transplantation conditioning ...
Athena L. Russell +9 more
doaj +1 more source
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Advanced Science, EarlyView.Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source
Analytical Cellular Pathology, 2000 The glycophoryn A (GPA) assay evaluates somatic in vivo mutations. It is considered a cumulative biodosimeter for genotoxic exposures and is under evaluation in cancer risk assessment.
Monica Neri +8 more
doaj +1 more source
Mutagenic impact on fish of runoff events in agricultural areas in south-west France [PDF]
, 2011 When heavy rainfall follows herbicide application, the intense surface runoff causes stream water contamination. Aquatic organisms are then briefly exposed to a complex mixture of contaminants.
Pinelli, Eric +14 more
core +1 more source
Climate Risk Assessment - Charleston County, South Carolina
, 2023 As a result of climate change, flood risk is expected to increase throughout Charleston County. The probability of the 100-year rainfall event, a useful indicator of flood risk, will likely triple by the mid 21st century.
Woodwell Climate Research Center - Risk Program +2 more
core +1 more source
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Evaluation of occupational genotoxic risk in a Brazilian hospital
Genetics and Molecular Biology, 2000 Many therapeutic, diagnostic and prophylactic procedures used in hospitals are of potential genetic risk. An evaluation was made of genotoxic occupational risk in 42 workers from the Hospital de Clínicas de Porto Alegre, RS, Brazil, who had been ...
Sharbel Weidner Maluf, Bernardo Erdtmann
doaj +1 more source
Polycyclic aromatic hydrocarbon-induced signaling events relevant to inflammation and tumorigenesis in lung cells are dependent on molecular structure. [PDF]
PLoS ONE, 2014 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and occupational toxicants, which are a major human health concern in the U.S. and abroad.
Ross S Osgood +6 more
doaj +1 more source
Genotoxic risk in rubber manufacturing industry: a systematic review
, 2014 A large body of evidence from epidemiological studies among workers employed in the rubber manufacturing industry has indicated a significant excess cancer risk in a variety of sites.
C. Bolognesi, A. Moretto
core +1 more source
, 2022 S.217-224Carcinogens are generally classified into two Groups: genotoxic and non-genotoxic. As the final product of genotoxic and non-genotoxic carcinogens is the same, i.e., a clone of genetically altered cells, it could be possible that non-genotoxic ...
Fahrig, R., Steinkamp-Zucht, A.
core +1 more source