Results 51 to 60 of about 36,448 (257)

Genotoxic Maillard byproducts in current phytopharmaceutical preparations of Echinodorus grandiflorus

Anais da Academia Brasileira de Ciências, 2014
Extracts of Echinodorus grandiflorus obtained from dried leaves by three different techniques were evaluated by bacterial lysogenic induction assay (Inductest) in relation to their genotoxic properties.
ELISANGELA C. LIMA-DELLAMORA, KASSIA C.V. WALDHELM, ADRIANA M. ALVES, CLAUDIA A.S. LAGE, ALVARO A.C. LEITÃO, RICARDO M. KUSTER   +5 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Comparative Study of Genotoxicity in Different Tobacco Related Habits using Micronucleus Assay in Exfoliated Buccal Epithelial Cells [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: Oral cancer is one of the most debilitating diseases afflicting mankind. Consumption of tobacco in various forms constitutes one of the most important etiological factors in initiation of oral cancer.
Pradeep MR, Yadavalli Guruprasad, Maji Jose, Kartikay Saxena, Deepa K, Vishnudas Prabhu   +5 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

Advanced Intelligent Systems, EarlyView.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard   +6 more
wiley   +1 more source

Comparative cytotoxicity and genotoxicity of commercial glyphosate-based herbicide formulations and co-formulants in human leukocyte and hepatocyte cell lines

Frontiers in Toxicology
BackgroundRisk assessments usually test active ingredients but not full commercial formulations. We compared cytotoxic and genotoxic effects of three glyphosate-based herbicides (Roundup Mega, Glyfos, Fozat-480) and two co-formulants (ROKAmin SR22 ...
Moustafa Sherif, Moustafa Sherif, Abderrahim Nemmar, Bassam R. Ali, Khadija Makame, Károly Nagy, Balázs Ádám   +6 more
doaj   +1 more source

Natural and Artificial Sweeteners a Blessing or Curse: A Phyto-genotoxic Study in Allium cepa L. Root Tip Cells

Journal of Applied Research in Plant Sciences
The study investigated the comparative phyto-genotoxic impacts of natural and artificial sweetener brands using the Allium cepa L. (onion) assay to predict potential phyto-genotoxic associated with long-term intake.
Sadaf Tabasum Qureshi, Sindhu Zahid, Muhammad Ramzan Laghari, Shafique Ahmed Rajper, Shamshad Ali Jarwar, Sooraj Kumar Bheel, Kainat Anwar Arian   +6 more
doaj   +1 more source

Mutagenic and genotoxic activity of particulate matter MP2,5, in Pamplona, North Santander, Colombia

Iatreia, 2012
Objective: To study the mutagenic and genotoxic activities of particulate material (MP2,5 collected in Pamplona, Norte de Santander, Colombia.Materials and methods: MP2,5 was monitored by means of a Partisol 2025 sequential air sampler with Plus Palmflex
Martínez Montañez, Mónica Liseth, Meléndez Gélvez, Iván, Quijano Parra, Alfonso   +2 more
doaj