Results 31 to 40 of about 5,806,293 (254)
Haematologica, 2008 Background The aim of this study was to analyze whether in chronic lymphocytic leukemia the cytosolic release of histone H1.2, a new apoptogenic mechanism induced by DNA damage, was associated with the presence of genetic abnormalities and with the ...
Eva Giné +7 more
doaj +1 more source
DNA adducts in fish following an oil spill exposure [PDF]
, 2006 On 12 December 1999, one third of the load of the Erika tanker, amounting to about 10,000 t crude oil flowed into sea waters close to the French Atlantic Coast.
Castegnaro, Marcel +3 more
core +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Scientific Opinion on the safety and efficacy of Hostazym C (endo-1,4-beta-glucanase) as feed additive for chickens for fattening, all other birds for fattening and piglets (weaned) [PDF]
EFSA Journal, 2013 Hostazym C is an enzyme preparation of endo-1,4-beta-glucanase produced by a non-genetically modified strain of Trichoderma citrinoviride. The results of an in vitro chromosomal aberration test and of an in vivo comet assay indicate the presence of ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj +1 more source
Cancer risk estimation of genotoxic chemicals based on target dose and a multiplicative model
, 1999 A mechanistic model and associated procedures are proposed for cancer risk assessment of genotoxic chemicals. As previously shown for ionizing radiation, a linear multiplicative model was found to be compatible with published experimental data for ...
Vaca, CE +3 more
core +1 more source
Comparative Evaluation of Genotoxicity of Captan in Amphibian Larvae (Xenopus laevis and Pleurodeles waltl) Using the Comet Assay and the Micronucleus Test [PDF]
, 2006 Captan (N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide) is a fungicide used to inhibit the growth of many types of fungi on plants used as foodstuffs.
Gauthier, Laury +8 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
FoodsThis paper reviews the published terminology, mathematical models, and the possible approaches used to characterise the risk of foodborne chemical hazards, particularly pesticides, metals, mycotoxins, acrylamide, and polycyclic aromatic hydrocarbons ...
Eva Doménech, Sebastián Martorell
doaj +1 more source
Statement on the BfR opinion regarding the toxicity of 2‐chloroethanol
EFSA Journal, 2022 In accordance with Art. 31(1) of Regulation (EC) No 178/2002, the Commission asked EFSA to provide a scientific review on the BfR opinion on the ‘Health risk assessment of ethylene oxide residues in sesame seeds’ (Opinion No 024/2021) regarding the ...
EFSA (European Food Safety Authority) +14 more
doaj +1 more source
Assessment of the genotoxicity of acrylamide
EFSA Journal, 2022 EFSA was requested to deliver a statement on a recent publication revisiting the evidence for genotoxicity of acrylamide (AA). The statement was prepared by a Working Group and was endorsed by the CONTAM Panel before its final approval.
European Food Safety Authority (EFSA) +4 more
doaj +1 more source