Results 21 to 30 of about 36,448 (257)

Evaluation of genotoxic activity of tenofovir disoproxil fumarate in human peripheral lymphocytes

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2016
Purpose: Antiretroviral drugs used in the treatment of HIV (Human Immunodeficiency Virus) iinfection, treat by preventing the proliferation of HIV in human body.
Kubra Kurt, Lale Donbak, Ahmet Kayraldiz
doaj   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Genotoxicity on Tradescantia pallida var. purpurea plants exposed to urban and rural environments in the metropolitan area of Porto Alegre, southern Brazil

Brazilian Journal of Biology
The Trad-MCN bioassay was used to investigate the genotoxicity on Tradescantia pallida var. purpurea plants exposed to variations in the environmental conditions in urban and rural sites in the metropolitan area of Porto Alegre, southern Brazil, over a ...
GM. Costa, A. Droste
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Assessing the spatial pattern of a river water quality in southern Brazil by multivariate analysis of biological and chemical indicators

Brazilian Journal of Biology
This study assessed the genotoxicity and chemical quality of the Rio dos Sinos, southern Brazil. During two years, bimonthly, cuttings of Tradescantia pallida var. purpurea with flower buds were exposed to river water samples from Caraá, Santo Antônio da
M. B. B. Cassanego, A. Droste
doaj   +1 more source

Pollen grain bioassay for environmental contamination biomonitoring

Acta Biologica Slovenica, 2004
Pollen grain bioassay near some highways was performed in 45 plant species for identification of environmental genotoxic impact on naturally growing plants due to environmental traffic contaminants. A relationship between the duration of heavy traffic on
Jasna Paradiž, Milan Lovka
doaj   +1 more source

Genotoxic risks in patients with COVID-19

Infection, Genetics and Evolution
The COVID-19 pandemic has caused numerous deaths worldwide. Despite the mitigation of infection manifestations in recent months, the possible consequences of the epidemic remain difficult to predict. Genotoxicity and subsequent development of neoplasms are possible outcomes. This review summarises the data on these questions.
Basaran, Nursen, Olga Szewczyk-Roszczenko, Piotr Roszczenko, Vassetzky, Yegor, Sjakste, Nikolajs   +4 more
openaire   +3 more sources

Probabilistic Risk Assessment of Metals, Acrylamide and Ochratoxin A in Instant Coffee from Brazil, Colombia, Mexico and Peru

Foods
This study analysed the probabilistic risk to consumers associated with the presence of iAs, Cd, Cr, Hg, Pb, acrylamide (AA) and ochratoxin A (OTA) in instant coffee from Brazil, Colombia, Mexico and Peru.
Grobert A. Guadalupe, Dorila E. Grandez-Yoplac, Erick Arellanos, Eva Doménech   +3 more
doaj   +1 more source

Scientific Opinion on the safety and efficacy of Hostazym C (endo-1,4-beta-glucanase) as feed additive for chickens for fattening, all other birds for fattening and piglets (weaned) [PDF]

EFSA Journal, 2013
Hostazym C is an enzyme preparation of endo-1,4-beta-glucanase produced by a non-genetically modified strain of Trichoderma citrinoviride. The results of an in vitro chromosomal aberration test and of an in vivo comet assay indicate the presence of ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Study on Cytotoxic and Genotoxic Potential of Bulgarian Rosa damascena Mill. and Rosa alba L. Hydrosols—In Vivo and In Vitro

Life, 2022
The Rosa alba L. and Rosa damascena Mill. growing in Bulgaria are known for their extremely fine essential oil and valuable hydrosols. Irrespectively of its wide use in human life, little research exists on the cytotoxic and genotoxic activity of the ...
Tsvetelina Gerasimova, Gabriele Jovtchev, Svetla Gateva, Margarita Topashka-Ancheva, Alexander Stankov, Tsveta Angelova, Ana Dobreva, Milka Mileva   +7 more
doaj   +1 more source