Results 1 to 10 of about 5,806,293 (254)

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project [PDF]

Frontiers in Toxicology, 2023
Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can be detected by an established in vitro and in vivo battery of genotoxicity assays.
Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, Sylvie Bortoli, Peter Bouwman, Albert Braeuning, Tanja Burgdorf, Xavier Coumoul, Kloé Debizet, Maria Dusinska, Norman Ertych, Jörg Fahrer, Verena Fetz, Ludovic Le Hégarat, Adela López de Cerain, Harm J. Heusinkveld, Kevin Hogeveen, Miriam N. Jacobs, Mirjam Luijten, Giuseppa Raitano, Cynthia Recoules, Elise Rundén-Pran, Mariam Saleh, Iva Sovadinová, Martina Stampar, Lea Thibol, Céline Tomkiewicz, Ariane Vettorazzi, Bob Van de Water, Naouale El Yamani, Bojana Zegura, Michael Oelgeschläger   +33 more
doaj   +4 more sources

Comparative cytotoxicity and genotoxicity of commercial glyphosate-based herbicide formulations and co-formulants in human leukocyte and hepatocyte cell lines [PDF]

Frontiers in Toxicology
BackgroundRisk assessments usually test active ingredients but not full commercial formulations. We compared cytotoxic and genotoxic effects of three glyphosate-based herbicides (Roundup Mega, Glyfos, Fozat-480) and two co-formulants (ROKAmin SR22 ...
Moustafa Sherif, Moustafa Sherif, Abderrahim Nemmar, Bassam R. Ali, Khadija Makame, Károly Nagy, Balázs Ádám   +6 more
doaj   +2 more sources

Multiple Pesticides and their Mixtures Tested for Genotoxicity in the Micronucleus Assays on Intestinal Caco‑2 Cells [PDF]

Annals of Global Health
Background: Widespread exposure to multiple pesticides might potentially represent a genotoxic risk to humans. However, the effects of these mixtures are largely unknown.
Francesca Truzzi, Eva Tibaldi, Roberta Noferini, Daria Sgargi, Simona Panzacchi, Gizem Nardali, Antonello Lorenzini, Silvia Dilloo, Eros D’Amen, Federica Gnudi, Giovanni Dinelli, Paul T. J. Scheepers, Daniele Mandrioli   +12 more
doaj   +2 more sources

A simple approach to assess the cancer risk of occupational exposure to genotoxic drugs in healthcare settings

Journal of Occupational Medicine and Toxicology, 2022
Background Several drugs for human use possess genotoxic properties as a necessary consequence of their intended therapeutic effect (e.g. antineoplastics).
Johannes Gerding, Lea Anhäuser, Udo Eickmann, Albert Nienhaus   +3 more
doaj   +1 more source

Genotoxicity of Mercury and Its Derivatives Demonstrated In Vitro and In Vivo in Human Populations Studies. Systematic Review

Toxics, 2021
Beside partial coverage in three reviews so far (1994, 2009, 2019), there is no review on genotoxic studies dealing with mercury (Hg) and human exposure using the most usual genotoxic assays: sister chromatid exchanges (SCE), chromosomal aberrations (CA),
Juana Sánchez-Alarcón, Mirta Milić, Lilia Patricia Bustamante-Montes, Keila Isaac-Olivé, Rafael Valencia-Quintana, Ninfa Ramírez-Durán   +5 more
doaj   +1 more source

p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress

Cell Death and Disease, 2021
Stem and progenitor cells are the main mediators of tissue renewal and repair, both under homeostatic conditions and in response to physiological stress and injury. Hematopoietic system is responsible for the regeneration of blood and immune cells and is
Lin Tze Tung, HanChen Wang, Jad I. Belle, Jessica C. Petrov, David Langlais, Anastasia Nijnik   +5 more
doaj   +1 more source

The Tradescantia pallida var. purpurea active bioassay for water monitoring: evaluating and comparing methodological conditions

Revista Ambiente & Água, 2014
Tradescantia pallida var. purpurea cuttings with flower buds are utilized in bioassays to diagnose genotoxic effects of water. The literature describes different substances used to adapt and recover the cuttings before and after exposure to water samples
Mara Betânia Brizola Cassanego, Gustavo Marques da Costa, Márcio Hisayuki Sasamori, Delio Endres Júnior, Camila Tamires Petry, Annette Droste   +5 more
doaj   +1 more source

Genotoxic changes in peripheral lymphocytes after therapeutic exposure to crude coal tar and ultraviolet radiation

Biomedical Papers, 2016
Aims: Goeckerman therapy is based on combined exposure to UV radiation (UVA, UVB) and crude coal tar (PAHs). Some indicators suggest a genotoxic hazard, however, the level of genotoxic risk of the therapy has not yet been investigated sufficiently.
Andrea Malkova, Renata Kohlerova, Zdenek Fiala, Kvetoslava Hamakova, Iva Selke-Krulichova, Lenka Borska   +5 more
doaj   +1 more source

What is the meaning of ‘A compound is carcinogenic’?

Toxicology Reports, 2018
Chemical Carcinogens are compounds which can cause cancer in humans and experimental animals. This property is attributed to many chemicals in the public discussion, resulting in a widespread perception of danger and threat.
Schrenk Dieter
doaj   +1 more source

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair [PDF]

BioDiscovery, 2014
The first part of this paper reviews the major achievements in the rapidly expanding field of research of individual capacity for repair of genotoxic damage.
Stoyan Chakarov, Rumena Petkova, George Ch Russev   +2 more
doaj   +3 more sources